Nebivolol Hydrochloride

• Catalog No.: Bio-0068
• CAS Number: 99200-09-6
• M. F.: C22H26ClF2NO4
• M. W.: 441.8959464

SYNONYMS

• IUPAC name: (1R)-1-[(2S)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-2-{[(2R)-2-[(2R)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-2-hydroxyethyl]amino}ethan-1-ol hydrochloride
• IUPAC Traditional name: (1R)-1-[(2S)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-2-{[(2R)-2-[(2R)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-2-hydroxyethyl]amino}ethan-1-ol hydrochloride
• Synonyms: Nebivololum; Nebicard-5; Nebipill; Nebilong; Nubeta; Bystolic; Lobivon; Nebilet; Nodon

DATABASE IDS

• CAS Number: 99200-09-6

PROPERTIES

• Application(s): Exhibits antianginal and antiischaemic effects
• Application(s): Antihypertensive agent
• Description: Isomers (1:1)
• Salt Data: HCl
• Mechanism of Action: Vasodilator
• Mechanism of Action: Beta 1 -Adrenoceptor antagonist

REFERENCES

• Eur. Pat., 1985, Janssen, 145 067; CA, 104, 5773, (synth, pharmacol)
• Van de Water, A. et al., J. Cardiovasc. Pharmacol., 1988, 11, 552
• Van Lommen, G. et al., J. Pharm. Belg., 1990, 45, 355, (synth, sar)
• Fitzgerald, J.D. et al., Drug Invest., Suppl. 1, 1991, 3, 1, (rev, pharmacokinet, pharmacol)
• Midol-Monnet, M. et al., J. Pharm. Pharmacol., 1991, 43, 504
• Janssens, W.J., J. Pharm. Belg., 1992, 47, 323, (pharmacol, rev)
• Peeters, O.M. et al., Acta Cryst. C, 1993, 49, 2154, (cryst struct)
• McNeely, W. et al., Drugs, 1999, 57, 633-651, (rev)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 914