Nateglinide

• Catalog No.: Bio-0067
• CAS Number: 105816-04-4
• M. F.: C19H27NO3
• M. W.: 317.42258

SYNONYMS

• IUPAC name: (2R)-3-phenyl-2-{[(1r,4r)-4-(propan-2-yl)cyclohexyl]formamido}propanoic acid
• IUPAC Traditional name: (2R)-3-phenyl-2-{[(1r,4r)-4-(propan-2-yl)cyclohexyl]formamido}propanoic acid
• Synonyms: Starsis; Fastic; Starlix

DATABASE IDS

• CAS Number: 105816-04-4

PROPERTIES

• Application(s): Oral hypoglycaemic agent
• Application(s): Antidiabetic agent
• Mechanism of Action: Stimulats the release of insulin from the pancreas by closing ATP-dependent potassium channels in the membrane of the betta-cells

REFERENCES

• Fujita, T. et al., Biochem. Pharmacol., 1996, 52, 407-411, (pharmacol)
• Takesda, H. et al., Bioorg. Med. Chem. Lett., 1996, 4, 1771-1781, (metab)
• Ono, I. et al., J. Chromatogr., B: Biomed. Appl., 1996, 678, 384-387; 1997, 692, 397-404, (hplc)
• Ikenoue, T. et al., Br. J. Pharmacol., 1997, 120, 137-145; 1191-1198, (pharmacol)
• Dunn, C.J. et al., Drugs, 2000, 60, 607-615, (rev)
• Eur. Pat., 1986, Ajinomoto, 196 222; CA, 106, 85057d, (synth, pharmacol)
• Hirose, H. et al., Pharmacology, 1994, 48, 205-210; 1995, 50, 175-181; 51, 245-253, (pharmacol)
• Akiyoshi, M. et al., Am. J. Physiol., 1995, 268, E185-E193, (pharmacol)
• Malaisse, W.J. et al., Horm. Metab. Res., 1995, 27, 263-266, (pharmacol)