Minocycline

• Catalog No.: Bio-0062
• CAS Number: 10118-90-8
• M. F.: C23H27N3O7
• M. W.: 457.47638

SYNONYMS

• IUPAC name: (4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
• IUPAC Traditional name: (4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
• Synonyms: Arestin; Minomycin; Aknemin; Dynacin; Mino-Tabs; Akamin; Minocin; Minoderm; Solodyn; Sebomin

DATABASE IDS

• CAS Number: 10118-90-8

PROPERTIES

• Application(s): Effective against tetracycline resistant Staphylococci in mice
• Mechanism of Action: Inhibitory effect on 5-lipoxygenase,
• Mechanism of Action: inhibits apoptosis via attenuation of TNF-alpha

REFERENCES

• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 2, 1375B, (nmr)
• Martell, M.J. et al., J. Med. Chem., 1967, 10, 44, (synth, nmr)
• Church, R.F.C. et al., J.O.C., 1971, 36, 723, (synth)
• Bernadi, L. et al., Farmaco, Ed. Sci., 1975, 30, 736; CA, 83, 192913, (synth)
• Green, R. et al., Eur. J. Clin. Pharmacol., 1976, 10, 245, (pharmacol, deriv)
• Zbinovsky, V. et al., Anal. Profiles Drug Subst., 1977, 6, 323, (rev)
• Mazzola, E.P. et al., J. Pharm. Sci., 1980, 69, 229, (cmr)
• Nelis, H. et al., Drug Metab. Dispos., 1982, 10, 142, (metab)
• Jonas, M. et al., Ther. Drug Monit., 1982, 4, 137, (pharmacol)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 6867
• Curtis, R.D. et al., Can. J. Chem., 1991, 69, 834, (N-15 nmr)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 182
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, MQW100; MQW250