Losartan Potassium

• Catalog No.: Bio-0060
• CAS Number: 124750-99-8
• M. F.: C22H22ClKN6O
• M. W.: 461.00098

SYNONYMS

• IUPAC name: potassium 5-[2-(4-{[2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl}phenyl)phenyl]-1H-1,2,3,4-tetrazol-1-ide
• IUPAC Traditional name: potassium 5-[2-(4-{[2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl}phenyl)phenyl]-1H-1,2,3,4-tetrazol-1-ide
• Synonyms: Cozaar

DATABASE IDS

• CAS Number: 124750-99-8

PROPERTIES

• Application(s): Orally active antihypertensive agent
• Application(s): Used in the treatment of congestive heart failure
• Salt Data: K+
• Mechanism of Action: Angiotensin II AT1-receptor antagonist

REFERENCES

• Eur. Pat., 1989, du Pont de Nemours, 324 377; CA, 112, 118817f, (synth, pharmacol)
• Chiu, A.T. et al., J. Pharmacol. Exp. Ther., 1990, 252, 711; 726, (pharmacol)
• Timmermans, P.B.M. et al., Am. J. Hypertens., 1991, 4, 2755; 2885, (rev)
• Wong, P.C. et al., Cardiovasc. Drug Rev., 1991, 9, 317, (rev)
• Carini, D.J. et al., J. Med. Chem., 1991, 34, 2525, (synth, pmr, pharmacol)
• Timmermans, P.B.M. et al., Trends Pharmacol. Sci., 1991, 12, 55, (rev)
• Stearns, R.A. et al., Drug Metab. Dispos., 1992, 20, 281, (metab)
• Furtek, C.I. et al., J. Chromatogr., 1992, 573, 295, (hplc)
• Van Meel, J.C.A. et al., Arzneim.-Forsch., 1993, 43, 242, (rev, pharmacol)
• Ohtawa, M. et al., Br. J. Clin. Pharmacol., 1993, 35, 290, (pharmacokinet)
• Siegl, P.K.S., J. Hypertens., 1993, 11, S19, (rev)
• Larsen, R.D. et al., J.O.C., 1994, 59, 6391, (synth)
• Schricker, K. et al., Proc. Natl. Acad. Sci. U.S.A., 1995, 92, 8006, (pharmacol)
• Mavromoustakos, T. et al., J. Med. Chem., 1999, 42, 1714-1722, (nmr, conformn)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 899