Lamotrigine

• Catalog No.: Bio-0056
• CAS Number: 84057-84-1
• M. F.: C9H7Cl2N5
• M. W.: 256.09138

SYNONYMS

• IUPAC name: 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
• IUPAC Traditional name: 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
• Synonyms: Lamictal; Lamictin

DATABASE IDS

• CAS Number: 84057-84-1

PROPERTIES

• Application(s): Anticonvulsant
• Application(s): Used in the treatment of epilepsy and bipolar disorder
• Mechanism of Action: Inhibits release of excitatory amino acids via blockage of neuronal voltage-dependent sodium channels

REFERENCES

• Eur. Pat., 1982, Wellcome, 21 121; CA, 98, 89397d, (synth, pharmacol)
• Eur. Pat., 1985, Wellcome, 142 306; CA, 103, 142021, (synth, pharmacol)
• Miller, A.A. et al., Curr. Probl. Epilepsy, 1986, 4, 165, (rev)
• Cohen, A.F. et al., Clin. Pharmacol. Ther. (St. Louis), 1987, 42, 535, (metab)
• Janes, R.W. et al., Acta Cryst. C, 1989, 45, 129, (cryst struct)
• Antiepileptic Drugs, (Eds. Levy, R.H., et al), 4th edn., Raven Press, 1995, 300
• Fitton, A. et al., Drugs, 1995, 50, (rev, pharmacol)
• Burstein, A.H. et al., Pharmacotherapy (Carlisle, Mass.), 1995, 15, 129, (rev)
• Martindale, The Extra Pharmacopoeia, 31st edn., Pharmaceutical Press, 1996, 375
• Wang, S.-J. et al., Synapse (N.Y.), 1996, 24, 248, (pharmacol)
• Bartoli, A. et al., Ther. Drug Monit., 1997, 19, 100, (hplc)