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Lamotrigine

Catalog No. Bio-0056 Name InterBioScreen
CAS Number 84057-84-1 Website http://www.ibscreen.com
M. F. C9H7Cl2N5 Telephone +7 49652 40091
M. W. 256.09138 Fax
Purity Email screen@ibscreen.chg.ru
Storage Chembase ID: 437

SYNONYMS

IUPAC name
6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
IUPAC Traditional name
6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
Synonyms
Lamictal
Lamictin

DATABASE IDS

CAS Number 84057-84-1

PROPERTIES

Application(s) Anticonvulsant
Application(s) Used in the treatment of epilepsy and bipolar disorder
Mechanism of Action Inhibits release of excitatory amino acids via blockage of neuronal voltage-dependent sodium channels

DETAILS

REFERENCES

  • Eur. Pat., 1982, Wellcome, 21 121; CA, 98, 89397d, (synth, pharmacol)
  • Eur. Pat., 1985, Wellcome, 142 306; CA, 103, 142021, (synth, pharmacol)
  • Miller, A.A. et al., Curr. Probl. Epilepsy, 1986, 4, 165, (rev)
  • Cohen, A.F. et al., Clin. Pharmacol. Ther. (St. Louis), 1987, 42, 535, (metab)
  • Janes, R.W. et al., Acta Cryst. C, 1989, 45, 129, (cryst struct)
  • Antiepileptic Drugs, (Eds. Levy, R.H., et al), 4th edn., Raven Press, 1995, 300
  • Fitton, A. et al., Drugs, 1995, 50, (rev, pharmacol)
  • Burstein, A.H. et al., Pharmacotherapy (Carlisle, Mass.), 1995, 15, 129, (rev)
  • Martindale, The Extra Pharmacopoeia, 31st edn., Pharmaceutical Press, 1996, 375
  • Wang, S.-J. et al., Synapse (N.Y.), 1996, 24, 248, (pharmacol)
  • Bartoli, A. et al., Ther. Drug Monit., 1997, 19, 100, (hplc)