Home > Compound List > Product Information
Irinotecan_Molecular_structure_CAS_97682-44-5)
Click picture or here to close

Irinotecan

Catalog No. Bio-0054 Name InterBioScreen
CAS Number 97682-44-5 Website http://www.ibscreen.com
M. F. C33H38N4O6 Telephone +7 49652 40091
M. W. 586.67802 Fax
Purity Email screen@ibscreen.chg.ru
Storage Chembase ID: 642

SYNONYMS

IUPAC name
(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaen-7-yl 4-(piperidin-1-yl)piperidine-1-carboxylate
IUPAC Traditional name
(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaen-7-yl 4-(piperidin-1-yl)piperidine-1-carboxylate
Synonyms
Camptosar
Topotecin
Camptetin
Campto

DATABASE IDS

CAS Number 97682-44-5

PROPERTIES

Application(s) Antineoplastic agent
Application(s) Use is in colon cancer
Mechanism of Action Topoisomerase I inhibitor

DETAILS

REFERENCES

  • Boisseau, M. et al., Expert Opin. Invest. Drugs, 1996, 5, 613, (rev)
  • Henegar, K.E. et al., J.O.C., 1997, 62, 6588-6597, (synth)
  • Robert, J. et al., Drugs of Today (Barcelona), 1998, 34, 777-803, (rev)
  • Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 543
  • Nitta, K. et al., Recent Adv. Chemother., Proc. Int. Congr. Chemother., 14th, 1985, 1, 28, (synth, pharmacol)
  • Kunimoto, T. et al., Cancer Res., 1987, 47, 5944, (pharmacol)
  • Koike, K. et al., Gen. Pharmacol., 1989, 20, 763, (pharmacol)
  • Kaneda, N. et al., Cancer Res., 1990, 50, 1715, (metab)
  • Sawada, S. et al., Chem. Pharm. Bull., 1991, 39, 1446, (synth, trihydrate, pmr, uv, cmr, cryst struct, activity)
  • Atsumi, R. et al., Xenobiotica, 1991, 21, 1159, (metab)
  • Aiyama, R. et al., Chem. Pharm. Bull., 1992, 40, 2810, (uv, cd, bibl)
  • Burris, H.A. et al., Semin. Oncol., 1992, 19, 663, (use, rev)
  • Rivory, L.P. et al., Cancer Res., 1994, 54, 6330, (metab, human)
  • Curran, D.P. et al., Angew. Chem., Int. Ed., 1995, 34, 2683, (synth)
  • Wiseman, L.R. et al., Drugs, 1996, 52, 606, (rev)