Irbesartan

• Catalog No.: Bio-0053
• CAS Number: 138402-11-6
• M. F.: C25H28N6O
• M. W.: 428.52942

SYNONYMS

• IUPAC name: 2-butyl-3-({4-[2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1,3-diazaspiro[4.4]non-1-en-4-one
• IUPAC Traditional name: 2-butyl-3-({4-[2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1,3-diazaspiro[4.4]non-1-en-4-one
• Synonyms: Karvea; Avapro; Aprovel

DATABASE IDS

• CAS Number: 138402-11-6

PROPERTIES

• Application(s): Antihypertensive agent
• Mechanism of Action: Angiotensin II AT 1 -receptor antagonist

REFERENCES

• Pat. Coop. Treaty (WIPO), 1991, Sanofi, 91 14 679; CA, 116, 41453g, (synth, pharmacol)
• Bernhart, C.A. et al., J. Med. Chem., 1993, 36, 3371, (synth, pmr, pharmacol)
• Cazaubon, C. et al., J. Pharmacol. Exp. Ther., 1993, 265, 826, (pharmacol)
• Roccon, A. et al., Br. J. Pharmacol., 1994, 111, 145, (pharmacol)
• Lacour, C. et al., Eur. J. Pharmacol., 1994, 264, 307, (pharmacol)
• van den Meiracker, A.H. et al., Hypertension (Dallas), 1995, 25, 22, (pharmacol, human)
• Gillis, J.C. et al., Drugs, 1997, 54, 885-902, (pharmacol, rev)
• Bckei, Z. et al., Acta Cryst. C, 1998, 54, 808-810, (desmotropic forms, cryst. struct)
• Chando, T.J. et al., Drug Metab. Dispos., 1998, 26, 408-417, (metab)
• Ruilope, L., J. Hypertens., 1998, 15, S15-S20; S27-S33, (rev)
• Johnston, C.I., Expert Opin. Invest. Drugs, 1999, 8, 655-670
• Markham, A. et al., Drugs, 2000, 59, 1187-1206, (rev)