Imatinib Mesylate

• Catalog No.: Bio-0051
• CAS Number: 220127-57-1
• M. F.: C30H35N7O4S
• M. W.: 589.7084

SYNONYMS

• IUPAC name: N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide; methanesulfonic acid
• IUPAC Traditional name: N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide; methanesulfonic acid
• Synonyms: Glivec; Gleevec

DATABASE IDS

• CAS Number: 220127-57-1

PROPERTIES

• Application(s): Antineoplastic agent
• Application(s): Used in treating chronic myelogenous leukemia (CML), gastrointestinal stromal tumors (GISTs) and a number of other malignancies
• Salt Data: Mesylate
• Mechanism of Action: Tyrosine kinase inhibitor

REFERENCES

• Eur. Pat., 1993, Ciba-Geigy, 564 409; CA, 120, 107056w, (synth, pharmacol)
• Buchdunger, E. et al., Cancer Res., 1996, 56, 100-104, (pharmacol)
• Deininger, M.W.N. et al., Blood, 1997, 90, 3691-3698, (pharmacol)
• Deininger, M.W. et al., Cancer Res., 2000, 60, 2049-2055, (pharmacol)
• O'Dwyer, M.E. et al., Curr. Opin. Oncol., 2000, 12, 594-597, (rev)
• Gianni, M. et al., Blood, 2001, 97, 3234-3243, (pharmacol)
• Lyseng-Williamson, K. et al., Drugs, 2001, 61, 1765-1774, (rev)
• Mughal, T.I. et al., Eur. J. Cancer, 2001, 37, 561-568, (rev)