Granisetron Hydrochloride

• Catalog No.: Bio-0050
• CAS Number: 107007-99-8
• M. F.: C18H25ClN4O
• M. W.: 348.8703

SYNONYMS

• IUPAC name: 1-methyl-N-[(1S,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]-1H-indazole-3-carboxamide hydrochloride
• IUPAC Traditional name: 1-methyl-N-[(1S,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]-1H-indazole-3-carboxamide hydrochloride
• Synonyms: Kytril

DATABASE IDS

• CAS Number: 107007-99-8

PROPERTIES

• Application(s): Antiemetic
• Salt Data: HCl
• Mechanism of Action: 5HT3-receptor antagonist

REFERENCES

• Eur. Pat., 1986, 200 444; CA, 106, 119892, (synth, pharmacol)
• Bermudez, J. et al., J. Med. Chem., 1990, 33, 1924, (synth)
• Goa, K.L. et al., Drugs, 1991, 42, 805, (rev)
• Kudoh, S. et al., J. Chromatogr., B: Biomed. Appl., 1994, 660, 205-210, (hplc)
• Adams, V.R. et al., Ann. Pharmacother., 1995, 29, 1240, (rev, pharmacol)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 1193