Gemfibrozil

• Catalog No.: Bio-0048
• CAS Number: 25812-30-0
• M. F.: C15H22O3
• M. W.: 250.33338

SYNONYMS

• IUPAC name: 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid
• IUPAC Traditional name: 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid
• Synonyms: Lipur; Organolipid; Gemcor; Emfib; Lipozid; Hipolixan; Lopid

DATABASE IDS

• CAS Number: 25812-30-0

PROPERTIES

• Application(s): Antihyperlipidaemic drug
• Mechanism of Action: Increases activity of Peroxisome proliferator-activated receptor-alpha (PPAR-alpha)

REFERENCES

• U.S. Pat., 1973, 3 707 566; CA, 78, 58105q, (synth)
• Creger, P.L. et al., Proc. R. Soc. Med., (Suppl. 2), 1976, 69, 1, (pharmacol, metab, tox)
• U.S. Pat., 1979, 4 126 637; CA, 90, 121021z, (synth)
• Glueck, C., Am. J. Cardiol., 1983, 52, 31, (rev)
• Abraham, D.J. et al., J. Med. Chem., 1984, 27, 967, (synth, props)
• Todd, P.A. et al., Drugs, 1988, 36, 314, (rev)
• Zimetbaum, P. et al., J. Clin. Pharmacol., 1991, 31, 25, (pharmacol, rev)
• Peroxisomes: Biology and Importance in Toxicology and Medicine, (Eds. Gibson, G. et al), Taylor and Francis, 1993, (tox)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 4802, (synonyms)
• Alegret, M. et al., Br. J. Pharmacol., 1995, 114, 1351, (pharmacol)
• Spencer, C.M. et al., Drugs, 1996, 51, 982, (rev, pharmacol)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 1273
• Barter, P.J., J. Drug Eval. Cardiovasc. Med., 2002, 1, 13-39, (rev)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, GCK300