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Gemcitabine

Catalog No. Bio-0047 Name InterBioScreen
CAS Number 95058-81-4 Website http://www.ibscreen.com
M. F. C9H11F2N3O4 Telephone +7 49652 40091
M. W. 263.1981464 Fax
Purity Email screen@ibscreen.chg.ru
Storage Chembase ID: 179696

SYNONYMS

IUPAC name
4-amino-1-[(4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one
IUPAC Traditional name
4-amino-1-[(4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one
Synonyms
Gemzar

DATABASE IDS

CAS Number 95058-81-4

PROPERTIES

Application(s) Antineoplastic agent
Application(s) Antiviral agent
Application(s) Antimetabolite
Application(s) Antineoplastic agent for treatment of lung and pancreatic tumours
Application(s) Nucleoside transporter substrate
Mechanism of Action Nucleoside antimetabolite

DETAILS

REFERENCES

  • Hertel, L.W. et al., J.O.C., 1988, 53, 2406, (synth, pmr, cmr)
  • Plunkett, W. et al., Nucleosides Nucleotides, 1988, 8, 775, (rev)
  • Baker, C.H. et al., J. Med. Chem., 1991, 34, 1879, (pharmacol)
  • Chou, T.S. et al., Synthesis, 1992, 565, (synth, ir, uv, cmr, bibl)
  • Lund, B. et al., Cancer Treat. Rev., 1993, 19, 45, (use, rev)
  • Huang, P. et al., Cancer Chemother. Pharmacol., 1995, 36, 181, (pharmacol)
  • Freeman, K.B. et al., J. Chromatogr., B: Biomed. Appl., 1995, 665, 171, (hplc)
  • Kawai, M. et al., Xenobiotica, 1995, 25, 405, (metab, rat, dog)
  • Guchelaar, H.-J. et al., Cancer Treat. Rev., 1996, 22, 15, (rev)
  • Noble, S. et al., Drugs, 1997, 54, 447-472, (rev)
  • Burke, T. et al., J. Pharmacol. Exp. Ther., 1998, 286, 1333-1340, (pharmacol)
  • Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 538