Gefitinib

• Catalog No.: Bio-0046
• CAS Number: 184475-35-2
• M. F.: C22H24ClFN4O3
• M. W.: 446.9023632

SYNONYMS

• IUPAC name: N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine
• IUPAC Traditional name: N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine
• Synonyms: Iressa; Tarceva; Irressat

DATABASE IDS

• CAS Number: 184475-35-2

PROPERTIES

• Application(s): Gefitinib is a drug used in the treatment of certain types of cancer
• Mechanism of Action: It is the first selective inhibitor of epidermal growth factor receptor's (EGFR) tyrosine kinase domain
• Mechanism of Action: Gefitinib inhibits EGFR tyrosine kinase by binding to the adenosine triphosphate (ATP)-binding site of the enzyme.
• Mechanism of Action: Thus the function of the EGFR tyrosine kinase in activating the Ras signal transduction cascade is inhibited, and malignant cells are inhibited

REFERENCES

• 88th Annual Meeting of the American Association for Cancer Research, San Diego, California, USA, 12 -16 April 1997. Lecture, 4251