Fluconazole

• Catalog No.: Bio-0041
• CAS Number: 86386-73-4
• M. F.: C13H12F2N6O
• M. W.: 306.2707864

SYNONYMS

• IUPAC name: 2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol
• IUPAC Traditional name: 2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol
• Synonyms: Fungata; Elazor; Diflucan; Biozolene; Triflucan

DATABASE IDS

• CAS Number: 86386-73-4

PROPERTIES

• Application(s): Antifungal agent
• Application(s): Effective in single oral dose against vaginal candidiasis
• Application(s): Prophylactic treatment for AIDS patients
• Application(s): Not active against Aspergillus
• Mechanism of Action: Inhibitor of fungal cytochrome P450 enzyme 14alpha-demethylase

REFERENCES

• U.K. Pat., 1982, Pfizer, 2 099 818; CA, 99, 38467q, (synth, pharmacol)
• Grant, S.M. et al., Drugs, 1990, 39, 877, (rev)
• Cobos Garcia, F.J. et al., Farm. Clin., 1991, 8, 423, (rev)
• Morck, H., Pharm. Ztg., 1991, 136, 56; 60, (rev)
• Morita, K. et al., Chem. Pharm. Bull., 1992, 40, 1247, (pharmacol)
• Fluconazole, (Eds., Powderly, W.G. et al), Marius Press, 1992, (book)
• Urbak, S.F. et al., Ophthalmologica, 1994, 208, 147, (use, rev)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 3349, (synonyms)
• Goa, K.L. et al., Drugs, 1995, 50, 658, (rev, pharmacokinet)
• Pat. Coop. Treaty (WIPO), 1997, Pfizer, 97 28 169; CA, 127, 220800s, (fosfluconazole, synth, pharmacol)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 378