Desloratadine

• Catalog No.: Bio-0024
• CAS Number: 100643-71-8
• M. F.: C19H19ClN2
• M. W.: 310.82056

SYNONYMS

• IUPAC name: 13-chloro-2-(piperidin-4-ylidene)-4-azatricyclo[9.4.0.0^3,^8]pentadeca-1(11),3,5,7,12,14-hexaene
• IUPAC Traditional name: 13-chloro-2-(piperidin-4-ylidene)-4-azatricyclo[9.4.0.0^3,^8]pentadeca-1(11),3,5,7,12,14-hexaene
• Synonyms: Claramax; Aerius; Clarinex; Neoclarityn

DATABASE IDS

• CAS Number: 100643-71-8

PROPERTIES

• Application(s): It is a drug used to treat allergies
• Application(s): Metab. of loratadine
• Mechanism of Action: H1-antagonist

REFERENCES

• Barnett, A. et al., Agents Actions, 1984, 14, 590, (pharmacol)
• Pat. Coop. Treaty (WIPO), 1985, Schering, 85 03 707; CA, 104, 116091a, (desloratadine, synth, pharmacol)
• Villani, F.J. et al., Arzneim.-Forsch., 1986, 36, 1311, (synth)
• Batenhorst, R.L. et al., Eur. J. Clin. Pharmacol., 1986, 31, 247, (pharmacol)
• Kreutner, W. et al., Allergy (Copenhagen), 1987, 42, 57, (pharmacol)
• Bradley, C.M. et al., Eur. J. Clin. Pharmacol., 1987, 32, 419, (pharmacol)
• Hilbert, J. et al., J. Clin. Pharmacol., 1987, 27, 530; 694; 1988, 28, 234, (pharmacol)
• Clissold, S.P. et al., Drugs, 1989, 37, 42, (rev)
• Schumacher, D.P. et al., J.O.C., 1989, 54, 2242, (synth, pmr)
• Piwinski, J.J. et al., J.O.C., 1990, 55, 3341, (metab)
• Piwinski, J.J. et al., J. Med. Chem., 1991, 34, 457, (activity)
• Barnett, A. et al., Chron. Drug Discovery, 1993, 3, 83, (rev)
• Roman, I.J. et al., Clin. Rev. Allergy, 1993, 11, 89, (pharmacol, rev)
• Haria, M. et al., Drugs, 1994, 48, 617, (rev)
• Letari, O. et al., Eur. J. Pharmacol., 1994, 266, 219, (pharmacol)
• Johnson, R. et al., J. Chromatogr., B: Biomed. Appl., 1994, 657, 125, (gc)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 8869, (synonyms)
• Caballero, R. et al., Br. J. Pharmacol., 1997, 122, 796-798, (desloratadine, pharmacol)
• Molet, S. et al., Clin. Exp. Allergy, 1997, 27, 1167-1174, (desloratadine, pharmacol)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 413