Cisapride

• Catalog No.: Bio-0018
• CAS Number: 81098-60-4
• M. F.: C23H31ClFN3O5
• M. W.: 483.9607432

SYNONYMS

• IUPAC name: 4-amino-5-chloro-N-[(4S)-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-yl]-2-methoxybenzamide hydrate
• IUPAC Traditional name: 4-amino-5-chloro-N-[(4S)-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-yl]-2-methoxybenzamide hydrate
• Synonyms: Propulsin; Alimix; Kinet; Prepulsid; Arcasin; Cipril; Cyprid; Fisiogastrol; Kelosal; Propulsid; Pulsitil; Trautil

DATABASE IDS

• CAS Number: 81098-60-4

PROPERTIES

• Application(s): Stimulates gut smooth muscle
• Application(s): Increases gastrointestinal motility (prokinetic agent)
• Application(s): Used in the management of GI reflux, dyspepsia
• Salt Data: H2O
• Mechanism of Action: 5HT(4) agonist

REFERENCES

• Cooke, H.J. et al., Eur. J. Pharmacol., 1984, 98, 147, (pharmacol)
• Eur. Pat., 1985, Janssen, 76 530; CA, 99, 194812d, (synth)
• Van Daele, G.H.P. et al., Drug Dev. Res., 1986, 8, 225, (synth, pharmacol)
• Reyntjens, A. et al., Drug Dev. Res., 1986, 8, 251, (rev)
• McCallum, R.W. et al., Drugs, 1988, 36, 652, (rev)
• Woestenborghs, R. et al., J. Chromatogr., 1988, 424, 195, (hplc)
• Hopkins, S.J., Drugs of Today (Barcelona), 1989, 25, 637, (rev)
• Collin, S. et al., J. Mol. Struct., 1989, 214, 159-175, (cryst struct)
• Awouters, F.H.L. et al., Arzneim.-Forsch., 1991, 41, 631, (pharmacol)
• Barone, J.A. et al., Ann. Pharmacother., 1994, 28, 488, (pharmacol)
• Wiseman, L.R. et al., Drugs, 1994, 47, 116, (rev)
• Peeters, O.M. et al., Acta Cryst. C, 1997, 53, 597-599, (cryst struct, tartrate)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 1187
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, CMS237