Canrenone

• Catalog No.: Bio-0012
• CAS Number: 976-71-6
• M. F.: C22H28O3
• M. W.: 340.45592

SYNONYMS

• IUPAC name: (2R,2'R,10'R,15'S)-2',15'-dimethylspiro[oxolane-2,14'-tetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadecane]-6',8'-diene-5,5'-dione
• IUPAC Traditional name: (2R,2'R,10'R,15'S)-2',15'-dimethylspiro[oxolane-2,14'-tetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadecane]-6',8'-diene-5,5'-dione
• Synonyms: Spiroletan; Phanurane; Luvion; Contaren

DATABASE IDS

• CAS Number: 976-71-6

PROPERTIES

• Application(s): Diuretic
• Mechanism of Action: Aldosterone antagonist

REFERENCES

• Cella, J.A. et al., J.O.C., 1959, 24, 1109, (synth, uv)
• Haskins, N.J. et al., Biomed. Mass Spectrom., 1974, 1, 423, (ms)
• Ramsay, L.E. et al., Br. J. Clin. Pharmacol., 1976, 3, 607, (metab, pharmacol)
• Weeks, C.M. et al., Cryst. Struct. Commun., 1976, 5, 271, (cryst struct)
• Williamson, D.E., J. Pharm. Sci., 1976, 65, 138, (hplc, chromatog)
• Boreham, D.R. et al., Org. Mass Spectrom., 1979, 14, 442, (ms)
• Hickey, J.P. et al., J. Magn. Reson., 1980, 38, 501, (cmr)
• Highet, R.J. et al., Steroids, 1980, 35, 119, (cmr)
• Johnson, W.S. et al., J.A.C.S., 1982, 104, 3510, (synth, ()-form)
• Kojima, K. et al., J. Pharmacobio-Dyn., 1985, 8, 161
• Karim, A. et al., Curr. Clin. Pract. Ser., 1986, 35, 22; 47, (rev, pharmacol, metab)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 812