Candesartan Cilexetil

• Catalog No.: Bio-0011
• CAS Number: 145040-37-5
• M. F.: C33H34N6O6
• M. W.: 610.65966

SYNONYMS

• IUPAC name: 2-{[(cyclohexyloxy)carbonyl]oxy}ethyl 2-ethoxy-1-({4-[2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1H-1,3-benzodiazole-7-carboxylate
• IUPAC Traditional name: 2-{[(cyclohexyloxy)carbonyl]oxy}ethyl 2-ethoxy-1-({4-[2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1H-1,3-benzodiazole-7-carboxylate

DATABASE IDS

• CAS Number: 145040-37-5

PROPERTIES

• Application(s): Antihypertensive agent
• Application(s): Renoprotective effects
• Mechanism of Action: Angiotensin II receptor antagonist

REFERENCES

• Eur. Pat., 1991, Takeda, 459 136; CA, 116, 128924, (synth, pharmacol)
• Mizuno, K. et al., Life Sci., 1992, 51, PL183, (Candesartan cilexitil)
• Kubo, K. et al., J. Med. Chem., 1993, 36, 2182; 2343, (synth, pmr, ir, pharmacol)
• Shibouta, Y. et al., J. Pharmacol. Exp. Ther., 1993, 266, 114, (pharmacol)
• Morimoto, S. et al., Cardiovasc. Drug Rev., 1994, 12, 153, (rev)
• Arakawa, K. et al., J. Hypertens., Suppl. 9, 1994, 12, (pharmacol, rev)
• Flesch, M. et al., Eur. J. Pharmacol., 1995, 289, 399, (pharmacol)
• Delacrtaz, E. et al., Hypertension (Dallas), 1995, 25, 14, (pharmacol, man)
• Lee, J.W. et al., J. Chromatogr., B: Biomed. Appl., 1995, 670, 287, (hplc)
• McClellan, K.J. et al., Drugs, 1998, 56, 847-869, (rev)
• Matsunaga, H. et al., Chem. Pharm. Bull., 1999, 47, 182-186, (Candesartan ciloxetil, cmr, cryst struct)
• Drugs of Today (Barcelona), 1999, 35, 11-16; 105-115; 117-126