Bicalutamide

• Catalog No.: Bio-0007
• CAS Number: 90357-06-5
• M. F.: C18H14F4N2O4S
• M. W.: 430.3733728

SYNONYMS

• IUPAC name: (2R)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(4-fluorobenzenesulfonyl)-2-hydroxy-2-methylpropanamide
• IUPAC Traditional name: (2R)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(4-fluorobenzenesulfonyl)-2-hydroxy-2-methylpropanamide
• Synonyms: Casodex; Cosudex; Calutide; Kalumid

DATABASE IDS

• CAS Number: 90357-06-5

PROPERTIES

• Mechanism of Action: Antiandrogen
• Mechanism of Action: Prevent the action of androgens by blocking the receptors for androgens on the cells of tissues, for example, the cells of the prostate gland
• Application(s): Antiandrogen investigated for the treatment of advanced prostate cancer

REFERENCES

• Eur. Pat., 1984, ICI, 100 172; CA, 101, 54739v, (synth)
• Tucker, H. et al., J. Med. Chem., 1988, 31, 885; 954, (synth, resoln, pharmacol)
• Furr, B.J.A., Prog. Clin. Biol. Res., 1988, 260, 13, (rev)
• Cockshott, I.D. et al., Xenobiotica, 1991, 21, 1347, (pharmacol)
• Blackledge, G., Cancer (Philadelphia), Suppl., 1993, 72, 3830, (rev)
• Boyle, G.W. et al., Xenobiotica, 1993, 23, 781; 1241, (metab)
• Furr, B.J.A., Ann. N.Y. Acad. Sci., 1995, 761, 79, (rev)
• Schellhammer, P., Expert Opin. Invest. Drugs, 1999, 8, 849-860