Atorvastatin Calcium

• Catalog No.: Bio-0005
• CAS Number: 134523-03-8
• M. F.: C66H74CaF2N4O13
• M. W.: 1209.3875664

SYNONYMS

• IUPAC name: calcium bis((5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate) trihydrate
• IUPAC Traditional name: calcium bis((5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate) trihydrate
• Synonyms: Torvast; Xarator; Totalip; Lipitor

DATABASE IDS

• CAS Number: 134523-03-8

PROPERTIES

• Application(s): Antihypercholesterolaemic agent
• Salt Data: Ca2+, 3 H2O
• Mechanism of Action: HMG-CoA reductase inhibitor

REFERENCES

• Shaw, M.K. et al., Biochem. Biophys. Res. Commun., 1990, 170, 726, (pharmacol)
• Eur. Pat., 1991, Warner-Lambert, 409 281; CA, 115, 29107u, (synth, pharmacol)
• Roth, B.D. et al., J. Med. Chem., 1991, 34, 357; 463, (synth)
• Baumann, K.L. et al., Tet. Lett., 1992, 33, 2279; 2283, (synth, pmr)
• Kearney, A.S. et al., Pharm. Res., 1993, 10, 1461, (props)
• Dostal, L.A. et al., Teratology, 1994, 50, 387, (tox)
• Auerbach, B.J. et al., Atherosclerosis (Amsterdam), 1995, 115, 173, (pharmacol)
• Lea, A.P. et al., Drugs, 1997, 54, 828-847, (rev)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 1268