(S,S)-ICG 001

• Catalog No.: I163800
• CAS Number: 780757-88-2
• M. F.: C33H32N4O4
• M. W.: 548.63158

SYNONYMS

• IUPAC name: (6S,9aS)-N-benzyl-6-[(4-hydroxyphenyl)methyl]-8-(naphthalen-1-ylmethyl)-4,7-dioxo-octahydro-1H-pyrimido[1,2-a]piperazine-1-carboxamide
• IUPAC Traditional name: (6S,9aS)-N-benzyl-6-[(4-hydroxyphenyl)methyl]-8-(naphthalen-1-ylmethyl)-4,7-dioxo-tetrahydro-2H-pyrimido[1,2-a]piperazine-1-carboxamide
• Synonyms: (6S,9aS)-Hexahydro-6-[(4-hydroxyphenyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide

DATABASE IDS

• CAS Number: 780757-88-2

DETAILS

Description (English)

(S,S)-ICG 001 is a β-turn peptidomimetic molecule inhibitor of β-catenin-Tcf-mediated transcription.

REFERENCES

• McMillan, M., et al.: Drug Discov. Today, 10, 1467 (2005)
• Brantjes, H., et al.: Biol. Chem., 383, 255 (2005)
• Nusse, R., et al.: Cell Res., 15, 28 (2005)
• Eguchi, M., et al.: Med. Chem., 1, 467 (2005)