5-Fluorocytosine

• Catalog No.: F7129
• CAS Number: 2022-85-7
• M. F.: C4H4FN3O
• M. W.: 129.0924632

SYNONYMS

• Title: 5-氟胞嘧啶
• IUPAC name: 4-amino-5-fluoro-1,2-dihydropyrimidin-2-one
• IUPAC Traditional name: 5-fluorocytosine
• Synonyms: 4-氨基-5-氟-2(1H)-嘧啶酮; Flucytosine; 氟胞嘧啶; 4-amino-5-fluoro-2(1H)-pyrimidinone

DATABASE IDS

• MDL Number: MFCD00006035
• PubChem SID: 24894928
• EC Number: 217-968-7
• CAS Number: 2022-85-7
• Beilstein Number: 127285

PROPERTIES

• Empirical Formula (Hill Notation): C4H4FN3O
• Melting Point: 298-300 °C (dec.)(lit.)
• GHS Signal Word: Warning
• GHS Hazard statements: H361
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• GHS Precautionary statements: P281
• Risk Statements: 63
• RTECS: HA6040000
• Safety Statements: 36/37
• Storage Temperature: 2-8°C
• German water hazard class: 2

DETAILS

Description (English)

Application
Used in studies on TMP biosynthesis.
Biochem/physiol Actions
Nucleoside analog that has antifungal activities. 5-FC is deaminated by cytosine deaminase to product 5-fluorouracil, resulting in RNA miscoding. 5-Fluorocytosine inhibits DNA and RNA synthesis and interferes with ribosomal protein synthesis.
Packaging
1, 5 g in poly bottle

Description (简体中文)

Application
Used in studies on TMP biosynthesis.
Biochem/physiol Actions
具有抗真菌活性的核苷类似物。5-氟胞嘧啶通过胞嘧啶脱氨酶脱氨，得到 5-氟尿嘧啶，从而导致 RNA 错编。5-氟胞嘧啶抑制 DNA 和 RNA 的合成并干扰核糖体蛋白的合成。
包装
1, 5 g in poly bottle