Trizma® base

• Catalog No.: T6066
• CAS Number: 77-86-1
• M. F.: C4H11NO3
• M. W.: 121.13504
• Purity: ≥99.9% (titration)

SYNONYMS

• Title: Trizma® 碱
• IUPAC name: 2-amino-2-(hydroxymethyl)propane-1,3-diol
• IUPAC Traditional name: tris buffer
• Synonyms: 氨基丁三醇; 2-Amino-2-(hydroxymethyl)-1,3-propanediol; Tris base; Tris(hydroxymethyl)aminomethane; Trometamol; 2-氨基-2-(羟甲基)-1,3-丙二醇; Tris 碱; THAM; 三羟甲基氨基甲烷

DATABASE IDS

• CAS Number: 77-86-1
• EC Number: 201-064-4
• Beilstein Number: 741883
• PubChem SID: 24900345
• MDL Number: MFCD00004679

PROPERTIES

• abs.: A40%/290 ≤0.05
• Cation Traces: heavy metals (as Pb): ≤2 ppm
• Description: aminopeptidase substrate
• Grade: Biotechnology Performance Certified
• Impurities: DNase, RNase, protease, none detected
• Impurities: Endotoxin and Total Count Aerobic, Yeast, plus Mold, tested
• Impurities: ≤0.2% water (Karl Fischer)
• Linear Formula: NH2C(CH2OH)3
• Purity: ≥99.9% (titration)
• Quality Level: ELITE
• Suitability: cell culture tested
• Suitability: meets EP, USP testing specifications
• Useful pH Range: 7 - 9
• pKa: 8.1 (25°C)
• Boiling Point: 219-220 °C/10 mmHg(lit.)
• Melting Point: 167-172 °C(lit.)
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• RTECS: TY2900000
• Safety Statements: 26-36
• German water hazard class: 2

DETAILS

Description (English)

Application
Not tested for use in parenteral applications as specified in the EP monograph.
Other Notes
Easily compare specifications for Trizma products with the Trizma specification table.
The pH values of all buffers are temperature- and concentration-dependent. For Tris buffers, pH increases about 0.03 unit per °C decrease in temperature, and decreases 0.03-0.05 unit per ten-fold dilution.For precise applications, use a carefully calibrated pH meter with a glass/calomel combination electrode.
Legal Information
Trizma is a registered trademark of Sigma-Aldrich Co. LLC

Description (简体中文)

Application
未经过欧洲药典专论中所述肠外应用的测试。
Other Notes
便于将 Trizma 产品规格与 Trizma 规格表进行比较。
所有缓冲液的 pH 值与温度和浓度都有关。对于 Tris 缓冲液，温度每降低 1°C，pH 增加约 0.03 个单位，浓度每稀释 10 倍，pH 降低 0.03-0.05 个单位。 对于精确应用，使用带有玻璃/甘汞复合电极的经仔细校正的 pH 计。
法律信息
Trizma 注册商标 Sigma-Aldrich Co. LLC