Swainsonine

• Catalog No.: S8195
• CAS Number: 72741-87-8
• M. F.: C8H15NO3
• M. W.: 173.2096
• Purity: ≥98% (TLC)

SYNONYMS

• IUPAC name: (1S,2R,8R)-octahydroindolizine-1,2,8-triol
• IUPAC Traditional name: (1S,2R,8R)-octahydroindolizine-1,2,8-triol
• Synonyms: (1S,2R,8R,8aR)-1,2,8-Octahydroindolizidinetriol

DATABASE IDS

• Beilstein Number: 4175740
• CAS Number: 72741-87-8
• MDL Number: MFCD00017554
• PubChem SID: 24899779

PROPERTIES

• Biological Source: from Metarrhizium anisopliae
• Empirical Formula (Hill Notation): C8H15NO3
• Purity: ≥98% (TLC)
• Apperance: lyophilized powder
• GHS Signal Word: Warning
• GHS Hazard statements: H302-H312-H332
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P280
• Risk Statements: 20/21/22
• RTECS: NM2408666
• Safety Statements: 36
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Application
Swainsonine is a potent inhibitor of various α-mannosidases, especially of α-mannosidase II.3 It inhibits glycoprotein processing4 and also acts as immune modulator.3,5
Swainsonine is an indolizidine alkaloid from the plant Metarrhizium anisopliae that is used as a potent α-mannosidase inhibitor1. Product S8195 has been used in chemical inhibition assays of CHO Lec2 cells to inhibit glycosylation 2.
Biochem/physiol Actions
Swainsonine is a potent α-mannosidase inhibitor. It also has antimetastatic, antiproliferative, and immunomodulatory activity 1. It also inhibits glycoprotein processing.
Physical properties
Soluble in water, methanol, DMSO

Description (简体中文)

Application
Swainsonine is a potent inhibitor of various α-mannosidases, especially of α-mannosidase II.3 It inhibits glycoprotein processing4 and also acts as immune modulator.3,5
Swainsonine is an indolizidine alkaloid from the plant Metarrhizium anisopliae that is used as a potent α-mannosidase inhibitor1. Product S8195 has been used in chemical inhibition assays of CHO Lec2 cells to inhibit glycosylation 2.
Biochem/physiol Actions
Swainsonine is a potent α-mannosidase inhibitor. It also has antimetastatic, antiproliferative, and immunomodulatory activity 1. It also inhibits glycoprotein processing.
Physical properties
Soluble in water, methanol, DMSO