NAMES AND DATABASE IDS
NAMES AND DATABASE IDS
Names Database IDs
IUPAC name
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(1S,2R,8R)-octahydroindolizine-1,2,8-triol
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IUPAC Traditional name
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(1S,2R,8R)-octahydroindolizine-1,2,8-triol
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Synonyms
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(1S,2R,8R,8aR)-1,2,8-Octahydroindolizidinetriol
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Swainsonine
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CAS Number
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MDL Number
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Beilstein Number
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PubChem SID
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PubChem CID
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DATA SOURCES
DATA SOURCES
All Sources Commercial Sources Non-commercial Sources
CALCULATED PROPERTIES
CALCULATED PROPERTIES
JChem
Acid pKa
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13.284674
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H Acceptors
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4
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H Donor
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3
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LogD (pH = 5.5)
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-4.78174
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LogD (pH = 7.4)
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-3.4669168
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Log P
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-1.4067957
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Molar Refractivity
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43.1178 cm3
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Polarizability
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17.444298 Å3
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Polar Surface Area
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63.93 Å2
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Rotatable Bonds
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0
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Lipinski's Rule of Five
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true
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DETAILS
DETAILS
Sigma Aldrich
Sigma Aldrich -
S6640
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Application Swainsonine is a potent inhibitor of various α-mannosidases, especially of α-mannosidase II.1 It inhibits glycoprotein processing2 and also acts as immune modulator.1,3 |
Sigma Aldrich -
S8195
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Application Swainsonine is a potent inhibitor of various α-mannosidases, especially of α-mannosidase II.3 It inhibits glycoprotein processing4 and also acts as immune modulator.3,5 Swainsonine is an indolizidine alkaloid from the plant Metarrhizium anisopliae that is used as a potent α-mannosidase inhibitor1. Product S8195 has been used in chemical inhibition assays of CHO Lec2 cells to inhibit glycosylation 2. Biochem/physiol Actions Swainsonine is a potent α-mannosidase inhibitor. It also has antimetastatic, antiproliferative, and immunomodulatory activity 1. It also inhibits glycoprotein processing. Physical properties Soluble in water, methanol, DMSO |
Sigma Aldrich -
S9263
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Application Swainsonine is a potent inhibitor of various α-mannosidases, especially of α-mannosidase II.1 It inhibits glycoprotein processing2 and also acts as immune modulator.1,3 |
Sigma Aldrich -
86204
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Application Swainsonine is a potent inhibitor of various α-mannosidases, especially of α-mannosidase II.1 It inhibits glycoprotein processing2 and also acts as immune modulator.1,3 Other Notes Inhibitor of Golgi mannosidase II and hence glycoprotein biosynthesis4,5 |
PATENTS
PATENTS
PubChem Patent
Google Patent