JX401

• Catalog No.: J4774
• CAS Number: 349087-34-9
• M. F.: C21H25NO2S
• M. W.: 355.4937
• Purity: >98% (HPLC)

SYNONYMS

• IUPAC name: 4-benzyl-1-[2-methoxy-4-(methylsulfanyl)benzoyl]piperidine
• IUPAC Traditional name: 4-benzyl-1-[2-methoxy-4-(methylsulfanyl)benzoyl]piperidine
• Synonyms: 1-[2-Methoxy-4-(methylthio)benzoyl]-4-benzylpiperidine

DATABASE IDS

• CAS Number: 349087-34-9
• MDL Number: MFCD02038777

PROPERTIES

• Empirical Formula (Hill Notation): C21H25NO2S
• Purity: >98% (HPLC)
• Apperance: off-white solid
• Solubility: DMSO: >5 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H410
• European Hazard Symbols: Nature polluting (N)
• Personal Protective Equipment: Eyeshields, Gloves
• GHS Precautionary statements: P273-P501
• RID/ADR: UN 3077 9/PG 3
• Risk Statements: 50/53
• Safety Statements: 60-61
• Hazard Class: 9
• UN Number: 3077
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
JX401 is a potent non-cytotoxic, membrane permeable p38α inhibitor. It is highly specific for p38α with an IC50 value of 32 nM while showing no inhibition for p38γ even at 10 μM. JX401 rescued yeast growth in a dose-dependent manner in p38-expressing cultures and reversibly inhibited myoblast differentiation in mammalian cells in culture.

Description (简体中文)

Biochem/physiol Actions
JX401 is a potent non-cytotoxic, membrane permeable p38α inhibitor. It is highly specific for p38α with an IC50 value of 32 nM while showing no inhibition for p38γ even at 10 μM. JX401 rescued yeast growth in a dose-dependent manner in p38-expressing cultures and reversibly inhibited myoblast differentiation in mammalian cells in culture.