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Dexfenfluramine

Catalog No. DB01191 Name DrugBank
CAS Number 3239-44-9 Website http://www.ualberta.ca/
M. F. C12H16F3N Telephone (780) 492-3111
M. W. 231.2573496 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 456

SYNONYMS

IUPAC name
ethyl({1-[3-(trifluoromethyl)phenyl]propan-2-yl})amine
IUPAC Traditional name
fenfluramine
Brand Name
Adifax
Redux
Synonyms
Levofenfluramina [Spanish]
Dextrofenfluramine
Dexfenfluramina [Spanish]
Levofenfluraminum [Latin]
Levofenfluramine [INN]
Levofenfluramine
L-Fenfluramine
Dexfenfluraminum [Latin]
D-Fenfluramine
Dexafenfluramine
Dexfenfluramine Hydrochloride

DATABASE IDS

CAS Number 3239-44-9

PROPERTIES

Hydrophobicity(logP) 3.5

DETAILS

Description (English)
Item Information
Drug Groups illicit; approved; withdrawn
Description Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. It was for some years in the mid-1990s approved by the United States Food and Drug Administration for the purposes of weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was withdrawn.
Indication For the management of obesity including weight loss and maintenance of weight loss in patients on a reduced calorie diet
Pharmacology Used to treat diabetes and obesity, Dexfenfluramine decreases caloric intake by increasing serotonin levels in the brain’s synapses. Dexfenfluramine acts as a serotonin reuptake inhibitor. It also causes release of serotonin from the synaptosomes.
Toxicity Symptoms of overdose include respiratory failure and cardiac arrest leading to death.
Affected Organisms
Humans and other mammals
Absorption Well-absorbed from the gastrointestinal tract.
Half Life 17-20 hours
Protein Binding 36%
External Links
Wikipedia
RxList

REFERENCES