ethyl({1-[3-(trifluoromethyl)phenyl]propan-2-yl})amine

• ChemBase ID: 456
• Molecular Formular: C12H16F3N
• Molecular Mass: 231.2573496
• Monoisotopic Mass: 231.12348418
• SMILES: FC(F)(F)c1cc(CC(NCC)C)ccc1
• Canonical SMILES: CCNC(Cc1cccc(c1)C(F)(F)F)C
• InChI: InChI=1S/C12H16F3N/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15/h4-6,8-9,16H,3,7H2,1-2H3
• InChIKey: DBGIVFWFUFKIQN-UHFFFAOYSA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: ethyl({1-[3-(trifluoromethyl)phenyl]propan-2-yl})amine
• IUPAC Traditional name: fenfluramine
• Brand Name: Acino; Adipomin; Obedrex; Pesos; Ponderax Pa; Ponderex; Pondimin; Rotondin; Adifax; Redux
• Synonyms: DEA No. 1670; Fenfluramina [DCIT]; Fenfluramine Hydrochloride; Fenfluraminum [INN-Latin]; Fenfluramine; Levofenfluraminum [Latin]; Levofenfluramine [INN]; Levofenfluramine; L-Fenfluramine; Levofenfluramina [Spanish]; Dextrofenfluramine; Dexfenfluraminum [Latin]; D-Fenfluramine; Dexafenfluramine; Dexfenfluramina [Spanish]; Dexfenfluramine Hydrochloride; Dexfenfluramine

Database IDs

• CAS Number: 3239-44-9; 458-24-2
• PubChem SID: 46506096; 160963919
• PubChem CID: 3337

CALCULATED PROPERTIES

JChem

• H Acceptors: 1
• H Donor: 1
• LogD (pH = 5.5): 0.24381867
• LogD (pH = 7.4): 0.7935381
• Log P: 3.4714873
• Molar Refractivity: 59.2021 cm^3
• Polarizability: 21.97514 Å^3
• Polar Surface Area: 12.03 Å^2
• Rotatable Bonds: 5
• Lipinski's Rule of Five: true

ALOGPS 2.1

• Log P: 3.3
• LOG S: -4.03
• Solubility (Water): 2.15e-02 g/l

PROPERTIES

Physical Property

• Solubility: 412 mg/L
• Hydrophobicity(logP): 3.5

DETAILS

DrugBank - DB01191

• Drug Groups: illicit; approved; withdrawn
• Description: Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. It was for some years in the mid-1990s approved by the United States Food and Drug Administration for the purposes of weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was withdrawn.
• Indication: For the management of obesity including weight loss and maintenance of weight loss in patients on a reduced calorie diet
• Pharmacology: Used to treat diabetes and obesity, Dexfenfluramine decreases caloric intake by increasing serotonin levels in the brain’s synapses. Dexfenfluramine acts as a serotonin reuptake inhibitor. It also causes release of serotonin from the synaptosomes.
• Toxicity: Symptoms of overdose include respiratory failure and cardiac arrest leading to death.
• Affected Organisms: Humans and other mammals
• Absorption: Well-absorbed from the gastrointestinal tract.
• Half Life: 17-20 hours
• Protein Binding: 36%
• External Links: Wikipedia; RxList

DrugBank - DB00574

• Drug Groups: illicit; withdrawn
• Description: Fenfluramine was withdrawn from the U.S. market in 1997 after reports of heart valve disease and pulmonary hypertension, including a condition known as cardiac fibrosis.
• Indication: For the management of exogenous obesity as a short-term (a few weeks) adjunct in a regimen of weight reduction based on caloric restriction.
• Pharmacology: Used to treat obesity, Fenfluramine decreases caloric intake by increasing serotonin levels in the brain's synapses. Fenfluramine acts as a serotonin reuptake inhibitor. It also causes release of serotonin from the synaptosomes. This in turn increases serotonin transmission in the feeding centre of the brain which suppresses appetite.
• Toxicity: Agitation and drowsiness, confusion, flushing, tremor (or shivering), fever, sweating, abdominal pain, hyperventilation, and dilated non-reactive pupils seem frequent in fenfluramine overdosage. Reflexes may be either exaggerated or depressed and some patients may have rotary nystagmus. Tachycardia may be present, but blood pressure may be normal or only slightly elevated. Convulsions, coma, and ventricular extrasystoles, culminating in ventricular fibrillation, and cardiac arrest, may occur at higher dosages. Less than 5 mg/kg are toxic to humans. Five-ten mg/kg may produce coma and convulsions. Reported single overdoses have ranged from 300 to 2000 mg; the lowest reported fatal dose was a few hundred mg in a small child, and the highest reported nonfatal dose was 1800 mg in an adult. Most deaths were apparently due to respiratory failure and cardiac arrest. Toxic effects will appear within 30 to 60 minutes and may progress rapidly to potentially fatal complications in 90 to 240 minutes. Symptoms may persist for extended periods depending upon the dose ingested.
• Affected Organisms: Humans and other mammals
• Biotransformation: Hepatic.
• Absorption: Fenfluramine is well-absorbed from the gastrointestinal tract, and a maximal anorectic effect is generally seen after 2 to 4 hours.
• Half Life: 20 hours
• References: Roth BL: Drugs and valvular heart disease. N Engl J Med. 2007 Jan 4;356(1):6-9. [Pubmed]
• External Links: Wikipedia; RxList

REFERENCES

• Roth BL: Drugs and valvular heart disease. N Engl J Med. 2007 Jan 4;356(1):6-9. Pubmed