NAMES AND DATABASE IDS
NAMES AND DATABASE IDS
Names Database IDs
IUPAC name
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4-{[1-(dimethylamino)-3-{2-[2-(3-methoxyphenyl)ethyl]phenoxy}propan-2-yl]oxy}-4-oxobutanoic acid hydrochloride
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IUPAC Traditional name
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sarpogrelate hydrochloride
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4-{[1-(dimethylamino)-3-{2-[2-(3-methoxyphenyl)ethyl]phenoxy}propan-2-yl]oxy}-4-oxobutanoic acid hydrochloride
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Synonyms
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Sarpogrelate hydrochloride
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Anplag
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Butanedioic acid 1-[2-(dimethylamino)-1-[[2-[2-(3-methoxyphenyl)ethyl]phenoxy]methyl]ethyl] ester hydrochloride
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MCI 9042
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Succinic acid mono-(1-dimethylaminomethyl-2-(2-[2-(3-methoxyphenyl)et hyl]phenoxy)ethyl) ester hydrochloride
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Sarpogrelate hydrochloride
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CAS Number
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MDL Number
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PubChem SID
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PubChem CID
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DATA SOURCES
DATA SOURCES
All Sources Commercial Sources Non-commercial Sources
CALCULATED PROPERTIES
CALCULATED PROPERTIES
JChem
Acid pKa
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3.7819445
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H Acceptors
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6
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H Donor
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1
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LogD (pH = 5.5)
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1.1198967
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LogD (pH = 7.4)
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1.0684103
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Log P
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1.1228089
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Molar Refractivity
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117.349 cm3
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Polarizability
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46.033474 Å3
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Polar Surface Area
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85.3 Å2
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Rotatable Bonds
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14
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Lipinski's Rule of Five
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true
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DETAILS
DETAILS
Selleck Chemicals
Sigma Aldrich
TRC
Selleck Chemicals -
S2019
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Biological Activity: Sarpogrelate hydrochloride is a selective 5-HT2A receptor antagonist to 5-HT2A, 5-HT2C and 5-HT2B receptors with pKi of 8.52, 7.43 and 6.57, respectively.Sarpogrelate hydrochloride reveals selectivity over 5-HT1, 5-HT3, 5-HT4 H1, H2, M3, α1-adrenergic, α2-adrenergic and β-adrenergic receptors. Additionally, Sarpogrelate hydrochloride displays cardioprotective activity in vivo. [1] Sarpogrelate hydrochloride improves vascular function in patients with peripheral arterial disease. Sarpogrelate hydrochloride blocks serotonin-induced platelet aggregation, and has applications in the treatment of many diseases including diabetes mellitus, Buerger’s disease, Raynaud’s disease, coronary artery disease, angina pectoris, and atherosclerosis. [2]References on Sarpogrelate HCl[1] J Cardiovasc Pharmacol., 2007, 49(4):221-7[2] http://en.wikipedia.org/wiki/Sarpogrelate, , |
Sigma Aldrich -
S5451
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Biochem/physiol Actions Sarapogrelate hydrochloride is a potent and selective 5-HT2A receptor antagonist. It exhibits analgesic effects in numerous animal studies.1 |
Toronto Research Chemicals -
S142300
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Sarpogrelate hydrochloride is a potent and selective 5-HT2A receptor antagonist and is used as an antiplatelet agent. It has been reported to increase erythrocyte deformability and suppress shear stress-induced hemolysis. |
REFERENCES
REFERENCES
From Suppliers
Google Scholar
PubMed
Google Books
- • Miyazaki M, et al. J Cardiovasc Pharmacol. 2007;49(4):221-7.
- • Skoularigis, J., et al.: Am. J. Cardiol., 71, 587 (1993)
- • Hara, H., et al.: Thromb. Haemost., 66, 484 (1993)
- • Nagatomo, T., et al.: Pharmacol. Ther., 104, 59 (1993)
- • Kikumoto, R. et al. , J. Med. Chem. , 1990, 33 , 1818, (synth, pharmacol)
- • Hara, H. et al. , Arzneim.-Forsch. , 1991, 41 , 616, (pharmacol)
- • Hara, H. et al. , Thromb. Haemostasis , 1991, 66 , 484, (pharmacol)
- • Rabasseda, X. et al. , Drugs of Today (Barcelona) , 1994, 30 , 43, (rev)
- • Kanamori, A. et al. , Life Sci. , 1994, 55 , PL365, (pharmacol)
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PATENTS
PATENTS
PubChem Patent
Google Patent