Home > Compound List > Compound details
10347-81-6 molecular structure
click picture or here to close

methyl(3-{tetracyclo[6.6.2.02,7.09,14]hexadeca-2(7),3,5,9(14),10,12-hexaen-1-yl}propyl)amine hydrochloride

ChemBase ID: 73059
Molecular Formular: C20H24ClN
Molecular Mass: 313.86426
Monoisotopic Mass: 313.15972745
SMILES and InChIs

SMILES:
c1ccc2c(c1)C1(c3c(C2CC1)cccc3)CCCNC.Cl
Canonical SMILES:
CNCCCC12CCC(c3c1cccc3)c1c2cccc1.Cl
InChI:
InChI=1S/C20H23N.ClH/c1-21-14-6-12-20-13-11-15(16-7-2-4-9-18(16)20)17-8-3-5-10-19(17)20;/h2-5,7-10,15,21H,6,11-14H2,1H3;1H
InChIKey:
NZDMFGKECODQRY-UHFFFAOYSA-N

Cite this record

CBID:73059 http://www.chembase.cn/molecule-73059.html

Collapse All Expand All

NAMES AND DATABASE IDS

NAMES AND DATABASE IDS

Names Database IDs
IUPAC name
methyl(3-{tetracyclo[6.6.2.02,7.09,14]hexadeca-2(7),3,5,9(14),10,12-hexaen-1-yl}propyl)amine hydrochloride
methyl(3-{tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaen-1-yl}propyl)amine hydrochloride
IUPAC Traditional name
maprotiline hydrochloride
methyl(3-{tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaen-1-yl}propyl)amine hydrochloride
Synonyms
3-(9,10-dihydro-9,10-ethanoanthracen-9-yl)-N-methylpropan-1-amine hydrochloride
Deprilept
Ludiomil
Psymion
Maprotiline hydrochloride
9-(γ-Methylaminopropyl)-9,10-dihydro-9,10-ethanoanthracene hydrochloride
Maprotiline hydrochloride
CAS Number
10347-81-6
EC Number
233-758-8
MDL Number
MFCD00079464
PubChem SID
24278576
162037979
PubChem CID
71478

DATA SOURCES

DATA SOURCES

All Sources Commercial Sources Non-commercial Sources
Data Source Data ID
PubChem 71478 external link

CALCULATED PROPERTIES

CALCULATED PROPERTIES

JChem
H Acceptors H Donor
LogD (pH = 5.5) 1.1368963  LogD (pH = 7.4) 1.4832375 
Log P 4.3721046  Molar Refractivity 99.3017 cm3
Polarizability 34.660324 Å3 Polar Surface Area 12.03 Å2
Rotatable Bonds Lipinski's Rule of Five true 

PROPERTIES

PROPERTIES

Physical Property Safety Information Pharmacology Properties Product Information Bioassay(PubChem)
Solubility
H2O: soluble50 mg/mL expand Show data source
Apperance
white powder expand Show data source
Storage Condition
-20°C expand Show data source
RTECS
KJ4555000 expand Show data source
European Hazard Symbols
Harmful Harmful (Xn) expand Show data source
German water hazard class
3 expand Show data source
Risk Statements
22 expand Show data source
GHS Pictograms
GHS07 expand Show data source
GHS Signal Word
Warning expand Show data source
GHS Hazard statements
H302 expand Show data source
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves expand Show data source
Target
Reuptake inhibitor expand Show data source
Purity
>99% (HPLC) expand Show data source
Salt Data
HCl expand Show data source
hydrochloride expand Show data source

DETAILS

DETAILS

Selleck Chemicals Selleck Chemicals Sigma Aldrich Sigma Aldrich
Selleck Chemicals - S2517 external link
Research Area: Neurological Disease
Biological Activity:
Maprotiline hydrochloride (Deprilept, Ludiomil, Psymion) is a selective noradrenalin re-uptake inhibitor and a tetracyclic antidepressant. Maprotiline hydrochloride (Deprilept, Ludiomil, Psymion) acts primarily by potentiation of central adrenergic synapses by blocking reuptake of norepinephrine at nerve endings. The pharmacologic action of Maprotiline hydrochloride (Deprilept, Ludiomil, Psymion) is thought to be responsible for the drug’s antidepressant and anxiolytic effects. Maprotiline hydrochloride (Deprilept, Ludiomil, Psymion) is indicated for the treatment of depressive illness in patients with depressive neurosis (dysthymic disorder) and manic-depressive illness, depressed type (major depressive disorder). Maprotiline hydrochloride (Deprilept, Ludiomil, Psymion) is also effective for the relief of anxiety associated with depression. [1][2]
Sigma Aldrich - M9651 external link
Biochem/physiol Actions
Selective norepinephrine uptake inhibitor.

REFERENCES

REFERENCES

From Suppliers Google Scholar IconGoogle Scholar PubMed iconPubMed Google Books IconGoogle Books
  • • http://en.wikipedia.org/wiki/Maprotiline
  • Searching...Please wait...

PATENTS

PATENTS

PubChem iconPubChem Patent Google Patent Search IconGoogle Patent

INTERNET

INTERNET

Baidu iconBaidu google iconGoogle