NAMES AND DATABASE IDS
NAMES AND DATABASE IDS
Names Database IDs
IUPAC name
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1-methyl-N-{9-methyl-9-azabicyclo[3.3.1]nonan-3-yl}-1H-indazole-3-carboxamide hydrochloride
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IUPAC Traditional name
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GRAN hydrochloride
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granisetron hydrochloride
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Synonyms
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1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide Hydrochloride
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BRL-43694A
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1-METHYL-1H-INDAZOLE-3-CARBOXYLIC ACID (9-METHYL-9-AZA-BICYCLO[3.3.1]NON-3-YL)-AMIDE HYDROCHLORIDE
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Kytril
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Granisetron Hydrochloride
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CAS Number
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PubChem SID
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PubChem CID
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DATA SOURCES
DATA SOURCES
All Sources Commercial Sources Non-commercial Sources
CALCULATED PROPERTIES
CALCULATED PROPERTIES
JChem
Acid pKa
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14.750399
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H Acceptors
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3
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H Donor
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1
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LogD (pH = 5.5)
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-1.3230767
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LogD (pH = 7.4)
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0.2712485
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Log P
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1.8768568
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Molar Refractivity
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101.8257 cm3
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Polarizability
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35.897053 Å3
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Polar Surface Area
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50.16 Å2
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Rotatable Bonds
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2
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Lipinski's Rule of Five
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true
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DETAILS
DETAILS
Selleck Chemicals
TRC
Selleck Chemicals -
S1345
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Research Area: Neurological Disease Biological Activity: Granisetron HCl is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. Its main effect is to reduce the activity of the vagus nerve. It does not have much effect on vomiting due to motion sickness. This drug does not have any effect on dopamine receptors or muscarinic receptors. [1] |
Toronto Research Chemicals -
G780000
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A specific serotonin (5HT3) receptor antagonist. Used as an antiemetic. Granisetron HCl is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. Its main effect is to reduce the activity of the va |
REFERENCES
REFERENCES
From Suppliers
Google Scholar
PubMed
Google Books
- • en.wikipedia.org/wiki/Granisetron_hydrochloride
- • Kilpatrick, G.J., et al.: Nature, 330, 746 (1987)
- • Durig, T., et al.: J. Pharm. Sci., 86, 1092 (1987)
- • Yuasa, H., et al.: Chem. Pharm. Bull., 44, 1361 (1987)
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PATENTS
PATENTS
PubChem Patent
Google Patent