pyridin-2-amine

• ChemBase ID: 52258
• Molecular Formular: C5H6N2
• Molecular Mass: 94.11454
• Monoisotopic Mass: 94.0530982
• SMILES: c1(ccccn1)N
• Canonical SMILES: Nc1ccccn1
• InChI: InChI=1S/C5H6N2/c6-5-3-1-2-4-7-5/h1-4H,(H2,6,7)
• InChIKey: ICSNLGPSRYBMBD-UHFFFAOYSA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: pyridin-2-amine
• IUPAC Traditional name: 2-aminopyridine
• Synonyms: 1,2-Dihydro-2-iminopyridine; NSC 431; 2-Aminopyridine; Pyridin-2-amine; 2-Aminopyridine 99%; pyridin-2-amine; α-Aminopyridine; 2-Aminopyridine; 2-AP; 2-Pyridinamine; 2-Pyridylamine; 2-吡啶胺; 邻氨基吡啶; 2-氨基吡啶

Database IDs

• CAS Number: 504-29-0
• EC Number: 207-988-4
• MDL Number: MFCD00006312
• Beilstein Number: 105785
• Merck Index: 14473
• PubChem SID: 24891282; 24891283; 162057021; 24862714
• PubChem CID: 10439
• CHEMBL: 21619
• Chemspider ID: 10008
• Wikipedia Title: 2-Aminopyridine

CALCULATED PROPERTIES

• H Acceptors: 2
• H Donor: 1
• LogD (pH = 5.5): -0.60386604
• LogD (pH = 7.4): 0.42012146
• Log P: 0.521105
• Molar Refractivity: 28.915 cm^3
• Polarizability: 10.568171 Å^3
• Polar Surface Area: 38.91 Å^2
• Rotatable Bonds: 0
• Lipinski's Rule of Five: true

PROPERTIES

Physical Property

• Solubility: Dichloromethane; Methanol; Water
• Apperance: colourless solid; Pale Yellow Low Melting Solid
• Melting Point: 54-58 °C; 54-58 °C(lit.); 54-60°C; 56 °C; 56°C; 56-58°C; 56-60°C; 58-60°C; 59-60 °C
• Boiling Point: 204 °C; 204°C; 204-210 °C(lit.); 204-211°C; 209-211°C; 210 °C
• Flash Point: 197.6 °F; 92 °C; 92°C; 92°C(197°F)
• Vapor Pressure: 0.8 mm Hg at 25 °C.
• Vapor Density: 3.25 (air = 1)

Safety Information

• Storage Condition: Refrigerator, Under Inert Atmosphere; Room Temperature (15-30°C)
• Storage Warning: TOXIC; Toxic/Irritant/Moisture Sensitive/Store under Argon
• RTECS: US1575000
• European Hazard Symbols: Nature polluting (N); Toxic (T)
• UN Number: 2671; UN2671
• German water hazard class: 3
• Hazard Class: 6.1
• Packing Group: 2; II
• Australian Hazchem: 2X
• Risk Statements: 21-23/25-36/37/38-51/53; 21-25-36/37/38; R:25
• Safety Statements: 26-36/37/39-45; 26-36/37-45-61; S:28-29-36/37/39-45
• EU Classification: T2
• EU Hazard Identification Number: 6.1B
• Emergency Response Guidebook(ERG) Number: 153
• TSCA Listed: false; 是
• GHS Pictograms: GHS06; GHS09
• GHS Signal Word: Danger
• GHS Hazard statements: H301 + H311-H315-H319-H335; H301-H331-H312-H315-H319-H335-H411-H401
• GHS Precautionary statements: P261-P280-P301 + P310-P305 + P351 + P338-P312; P280H-P273-P270-P305+P351+P338-P309-P310
• Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• RID/ADR: UN 2671 6.1/PG 2

Product Information

• Purity: ~99%; ≥98.0% (NT); ≥99%; 95+%; 99%
• Grade: PESTANAL®, analytical standard; purum
• Empirical Formula (Hill Notation): C5H6N2

DETAILS

MP Biomedicals - 02150364

White to off-white crystals
Purity: ~99%

MP Biomedicals - 05206286

MP Biomedicals Rare Chemical collection

Sigma Aldrich - A77997

Packaging
100, 500 g in poly bottle
5 g in glass bottle

Sigma Aldrich - 09340

Application
Used to label neutral and acidic glycans for fluorescent and UV detection in HPLC.1 2-AP has also been used to derivatize sialyloligosaccharides for detection in FAB-MS.2

Sigma Aldrich - A77989

Packaging
100 g in poly bottle
25 g in glass bottle

Sigma Aldrich - 36685

Legal Information
PESTANAL is a registered trademark of Sigma-Aldrich Laborchemikalien GmbH

Toronto Research Chemicals - A628985

Compound has been shown to reversibly block voltage-dependent potassium channels, and is also a common impurity from the synthesis of compounds found in hair dyes

REFERENCES

• Williams, D.M., et al.: J. Biol. Chem., 275, 38127 (2000)
• Munoz-Caro, C., et al.: Biophys. Chem., 96, 1 (2000)