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15663-27-1 molecular structure
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dichloroplatinumdiamine

ChemBase ID: 397
Molecular Formular: Cl2H4N2Pt
Molecular Mass: 298.02916
Monoisotopic Mass: 296.9399445
SMILES and InChIs

SMILES:
Cl[Pt](Cl)(N)N
Canonical SMILES:
N[Pt](Cl)(Cl)N
InChI:
InChI=1S/2ClH.2H2N.Pt/h2*1H;2*1H2;/q;;2*-1;+4/p-2
InChIKey:
DQLATGHUWYMOKM-UHFFFAOYSA-L

Cite this record

CBID:397 http://www.chembase.cn/molecule-397.html

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NAMES AND DATABASE IDS

NAMES AND DATABASE IDS

Names Database IDs
IUPAC name
dichloroplatinumdiamine
IUPAC Traditional name
diamminedichloroplatinum
Brand Name
Abiplatin
Biocisplatinum
Briplatin
Carboquone
Cis Pt II
Cismaplat
Cisplatine
Cisplatyl
Citoplationo
Lederplatin
Neoplatin
Plastin
Platamine
Platiblastin
Platidiam
Platinex
Platinol
Platinol-AQ
Platinoxan
Randa
Synonyms
Cis-Diaminedichloroplatinum
Cis-Diamminedichloroplatinum
Diamminedichloroplatinum
CPDC
CPDD
DDP
DDPT
Cis-DDP
CACP
Platinum Ammine Chloride
Platinum Ammonium Chloride
Platinum Diamine Dichloride
Trans-DDP
Trans-Platinumdiammine Dichloride
Trans-Dichlorodiammine Platinum
Trans-Diamminedichloroplatinum
Trans-Diaminedichloroplatinum
Cisplatin
CAS Number
15663-27-1
PubChem SID
46504561
160963860
PubChem CID
2767
441203

DATA SOURCES

DATA SOURCES

All Sources Commercial Sources Non-commercial Sources
Data Source Data ID Price
Selleck Chemicals
S1166 external link Add to cart Please log in.

CALCULATED PROPERTIES

CALCULATED PROPERTIES

JChem
H Acceptors H Donor
LogD (pH = 5.5) -0.09342632  LogD (pH = 7.4) 0.03941444 
Log P 0.0414  Molar Refractivity 22.8408 cm3
Polarizability 15.92687 Å3 Polar Surface Area 52.04 Å2
Rotatable Bonds Lipinski's Rule of Five true 

PROPERTIES

PROPERTIES

Physical Property Safety Information Product Information Bioassay(PubChem)
Solubility
2530 mg/L expand Show data source
DMSO expand Show data source
Hydrophobicity(logP)
-2.19 expand Show data source
Storage Condition
-20°C expand Show data source
Salt Data
Free Base expand Show data source

DETAILS

DETAILS

DrugBank DrugBank Selleck Chemicals Selleck Chemicals
DrugBank - DB00515 external link
Item Information
Drug Groups approved
Description Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also includes carboplatin and oxaliplatin.
Indication For the treatment of metastatic testicular tumors, metastatic ovarian tumors and advanced bladder cancer.
Pharmacology Cisplatin is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.
Affected Organisms
Humans and other mammals
Half Life 20-30 minutes
Protein Binding Greater than 90%.
Elimination The parent compound, cisplatin, is excreted in the urine. Although small amounts of platinum are present in the bile and large intestine after administration of cisplatin, the fecal excretion of platinum appears to be insignificant.
Clearance * 15 - 16 L/h/m2 [After infusions of 100 mg/m2.]
External Links
Wikipedia
RxList
Drugs.com
Selleck Chemicals - S1166 external link
Research Area: cancer
Biological Activity:
Cisplatin is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, small cell lung cancer, ovarian cancer, lymphomas, and germ cell tumors. It was the first member of a class of anti-cancer drugs which now also includes carboplatin and oxaliplatin. These platinum complexes react in vivo, binding to and causing crosslinking of DNA which ultimately triggers apoptosis . [1] 

REFERENCES

REFERENCES

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  • • Rebillard A et al. Curr Med Chem. 2008;15(26):2656-63
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PATENTS

PATENTS

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