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6055-72-7 molecular structure
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2-aminoacetic acid

ChemBase ID: 31
Molecular Formular: C2H5NO2
Molecular Mass: 75.0666
Monoisotopic Mass: 75.03202841
SMILES and InChIs

SMILES:
OC(=O)CN
Canonical SMILES:
NCC(=O)O
InChI:
InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
InChIKey:
DHMQDGOQFOQNFH-UHFFFAOYSA-N

Cite this record

CBID:31 http://www.chembase.cn/molecule-31.html

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NAMES AND DATABASE IDS

NAMES AND DATABASE IDS

Names Database IDs
IUPAC name
2-aminoacetic acid
IUPAC Traditional name
glycine
Brand Name
Glycolixir
Glycosthene
Gyn-Hydralin
Padil
Aciport
Glicoamin
Glycocoll
Synonyms
Glycine, ACS
Glycine-2-3H
Glycine
GLYCINE, ELECTROPHORESIS GRADE
Additive Screening Solution 47/Fluka kit no 78374
Glycine solution
Glycine 1 M solution
2-Aminoacetic acid
Aminoacetic acid
Aminoethanoic acid
Gly
Glycine
Glycolixir
Hampshire Glycine
GLYCINE ACS REAGENT GRADE
6-Aminopurine HCl
ADENINE HYDROCHLORIDE
Glycocoll
G
GLYCINE FREE ACID
GLYCINE, USP GRADE
Glycinum
Aciport
Glicoamin
Glycosthene
Gyn-Hydralin
H 1
NSC 25936
NSC 2916
NSC 54188
Padil
2-Aminoacetic acid
H-Gly-OH
甘氨酸, ACS
乙氨酸
氨基乙酸
氨基醋酸
甘氨酸
甘氨酸
CAS Number
6055-72-7
56-40-6
21931-03-3
EC Number
231-791-2
200-272-2
MDL Number
MFCD00135793
MFCD00008131
Beilstein Number
635782
Merck Index
144491
PubChem SID
46508219
24895290
24860042
24873323
24901611
24895210
24849510
24895135
160963494
24895306
24865701
24895353
24895355
PubChem CID
750
CHEBI ID
15428
ATC CODE
B05CX03
CHEMBL
773
Chemspider ID
730
DrugBank ID
DB00145
FEMA ID
3287
IUPHAR ligand ID
727
KEGG ID
D00011
Unique Ingredient Identifier
TE7660XO1C
Wikipedia Title
Glycine
Council of Europe Number
4118
Flavis Number
17.034
E Number
E640

CALCULATED PROPERTIES

CALCULATED PROPERTIES

JChem ALOGPS 2.1
Acid pKa 2.307457  H Acceptors
H Donor LogD (pH = 5.5) -3.4094565 
LogD (pH = 7.4) -3.4150424  Log P -3.4094596 
Molar Refractivity 16.0034 cm3 Polarizability 6.549665 Å3
Polar Surface Area 63.32 Å2 Rotatable Bonds
Lipinski's Rule of Five true 
Log P -3.34  LOG S 0.87 
Solubility (Water) 5.52e+02 g/l 

PROPERTIES

PROPERTIES

Physical Property Safety Information Pharmacology Properties Product Information Bioassay(PubChem)
Solubility
1 M HCl: soluble1 M at 20 °C, clear, colorless expand Show data source
1 M HCl: soluble1 M, clear expand Show data source
1 M HCl: soluble1 M, clear, colorless expand Show data source
1 M HCl: soluble75 mg/L, clear, colorless (2.252g in 30mL) expand Show data source
24.99 g/100 mL (25 °C) in water expand Show data source
249 mg/mL at 25 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)] expand Show data source
H2O: soluble100 mg/mL expand Show data source
hydrochloric acid: soluble1 M at 20 °C, clear expand Show data source
soluble in ethanol, pyridine
insoluble in ether
expand Show data source
Apperance
Crystalline expand Show data source
powder expand Show data source
Powder expand Show data source
white solid expand Show data source
Melting Point
~250 °C (dec.) expand Show data source
182 °C expand Show data source
233 °C (decomposition) expand Show data source
240 °C (dec.)(lit.) expand Show data source
ca 245°C dec. expand Show data source
Boiling Point
>= 233 °C with decomposition expand Show data source
Density
1.03 g/mL at 20 °C expand Show data source
1.16 g/ml expand Show data source
1.595 expand Show data source
1.607 g/cm3 expand Show data source
Absorption Wavelength
A1M/260, 1 M HCl ≤0.01 expand Show data source
A1M/280 ≤0.15 expand Show data source
A1M/280, 1 M HCl ≤0.01 expand Show data source
λ: 260 nm Amax: 0.01 expand Show data source
λ: 280 nm Amax: 0.01 expand Show data source
Hydrophobicity(logP)
-3.4 expand Show data source
pKa
2.34 (carboxyl), 9.6 (amino) expand Show data source
2.35 expand Show data source
2.35 (25°C) expand Show data source
Fluorescence
λex 200-600; λem 300-800 nm (corresponds) expand Show data source
pH
5.9-6.4 (20 °C, 5%) expand Show data source
Organoleptic
sweet expand Show data source
Storage Condition
Room Temperature (15-30°C) expand Show data source
RTECS
MB7600000 expand Show data source
European Hazard Symbols
R expand Show data source
UN Number
2910 expand Show data source
MSDS Link
Download expand Show data source
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German water hazard class
1 expand Show data source
3 expand Show data source
Hazard Class
7 expand Show data source
TSCA Listed
expand Show data source
LD50
2600 mg/kg (mouse, oral) expand Show data source
Personal Protective Equipment
Eyeshields, Gloves expand Show data source
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter expand Show data source
RID/ADR
UN 2910 7 expand Show data source
Storage Temperature
20-25°C expand Show data source
2-8°C expand Show data source
Regulation Compliance
FCC expand Show data source
FDA 21 CFR (170.50) expand Show data source
FDA 21 CFR (172.320) expand Show data source
FDA 21 CFR (172.812) expand Show data source
Gene Information
rat ... Grin2a(24409) expand Show data source
Allergens
no known allergens expand Show data source
Purity
≥98.5% expand Show data source
≥99% expand Show data source
~99% expand Show data source
>99.5% expand Show data source
≥98.5% expand Show data source
≥98.5% (NT) expand Show data source
≥99% expand Show data source
≥99% (titration) expand Show data source
≥99% (TLC) expand Show data source
≥99.0% expand Show data source
≥99.0% (NT) expand Show data source
98% expand Show data source
98.5+% expand Show data source
99% expand Show data source
99.5+% expand Show data source
99.7-101% (calc. to the dried substance) expand Show data source
99-101% (based on anhydrous substance) expand Show data source
Grade
ACS expand Show data source
ACS reagent expand Show data source
analytical standard expand Show data source
certified reference material expand Show data source
ELECTROPHORESIS expand Show data source
EP expand Show data source
for electrophoresis expand Show data source
for luminescence expand Show data source
for molecular biology expand Show data source
JP expand Show data source
NI expand Show data source
Ph Eur expand Show data source
PharmaGrade expand Show data source
puriss. p.a. expand Show data source
purum expand Show data source
Reag. Ph. Eur. expand Show data source
REAGENT expand Show data source
reagent grade expand Show data source
ReagentPlus® expand Show data source
SAJ special grade expand Show data source
TraceCERT® expand Show data source
USP expand Show data source
Certificate of Analysis
Download expand Show data source
Download expand Show data source
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Suitability
complies for appearance of solution expand Show data source
complies for reaction against H2SO4 expand Show data source
in accordance for identity (IR) expand Show data source
meets EP, JP, USP testing specifications expand Show data source
suitable for cell culture expand Show data source
suitable for manufacturing use expand Show data source
Ignition Residue
≤0.05% expand Show data source
≤0.05% (as SO4) expand Show data source
≤0.1% expand Show data source
≤0.1% (as SO4) expand Show data source
Impurities
≤0.001% heavy metals (as Pb) expand Show data source
≤0.01% Ammonia expand Show data source
≤0.01% Insoluble matter expand Show data source
≤0.02% ammonium (NH4) expand Show data source
≤0.1% other ninhydrin-positive substances expand Show data source
≤0.1% water (Karl Fischer) expand Show data source
≤0.3% foreign amino acids expand Show data source
≤0.5% other ninhydrin-positive substances expand Show data source
18.6%±0.2% total nitrogen acc. to Kjeldahl expand Show data source
DNases, none detected expand Show data source
endotoxin, tested expand Show data source
H2SO4, passes test(darkened) expand Show data source
Hydrolyzable subsances, passes test expand Show data source
hydrolyzable substances, complies expand Show data source
Insoluble matter, passes filter test expand Show data source
insoluble matter, passes filter test expand Show data source
organic volatile impurities, complies (GC) expand Show data source
phosphatases, none detected expand Show data source
proteases, none detected expand Show data source
residual solvents, complies expand Show data source
RNases, none detected expand Show data source
Cation Traces
Al: ≤0.0005% expand Show data source
Al: ≤5 mg/kg expand Show data source
As: ≤0.00001% expand Show data source
As: ≤0.1 mg/kg expand Show data source
Ba: ≤0.0005% expand Show data source
Ba: ≤5 mg/kg expand Show data source
Bi: ≤0.0005% expand Show data source
Bi: ≤5 mg/kg expand Show data source
Ca: ≤0.001% expand Show data source
Ca: ≤10 mg/kg expand Show data source
Cd: ≤0.0005% expand Show data source
Cd: ≤5 mg/kg expand Show data source
Co: ≤0.0005% expand Show data source
Co: ≤5 mg/kg expand Show data source
Cr: ≤0.0005% expand Show data source
Cr: ≤5 mg/kg expand Show data source
Cu: ≤0.0005% expand Show data source
Cu: ≤5 mg/kg expand Show data source
Fe: ≤0.0005% expand Show data source
Fe: ≤5 mg/kg expand Show data source
heavy metals (as Pb): ≤0.002% expand Show data source
heavy metals (as Pb): ≤20 ppm expand Show data source
K: ≤0.005% expand Show data source
K: ≤50 mg/kg expand Show data source
Li: ≤0.0005% expand Show data source
Li: ≤5 mg/kg expand Show data source
Mg: ≤0.0005% expand Show data source
Mg: ≤5 mg/kg expand Show data source
Mn: ≤0.0005% expand Show data source
Mn: ≤5 mg/kg expand Show data source
Mo: ≤0.0005% expand Show data source
Mo: ≤5 mg/kg expand Show data source
Na: ≤0.005% expand Show data source
Na: ≤50 mg/kg expand Show data source
NH4+: ≤0.005% expand Show data source
NH4+: ≤0.02% expand Show data source
NH4+: ≤200 mg/kg expand Show data source
Ni: ≤0.0005% expand Show data source
Ni: ≤5 mg/kg expand Show data source
Pb: ≤0.0005% expand Show data source
Pb: ≤5 mg/kg expand Show data source
Sr: ≤0.0005% expand Show data source
Sr: ≤5 mg/kg expand Show data source
Zn: ≤0.0005% expand Show data source
Zn: ≤5 mg/kg expand Show data source
Antion Traces
chloride (Cl-): ≤0.005% expand Show data source
chloride (Cl-): ≤30 mg/kg expand Show data source
chloride (Cl-): ≤50 mg/kg expand Show data source
chloride (Cl-): ≤70 ppm expand Show data source
sulfate (SO42-): ≤0.005% expand Show data source
sulfate (SO42-): ≤20 mg/kg expand Show data source
sulfate (SO42-): ≤50 mg/kg expand Show data source
Biological Source
from non-animal source expand Show data source
Loss on Drying
≤0.05% loss on drying expand Show data source
≤0.05% loss on drying, 20 °C (HV) expand Show data source
≤0.05% loss on drying, 20°C (HV) expand Show data source
≤0.05% loss on drying, HV, 20 °C expand Show data source
≤0.2% loss on drying expand Show data source
≤0.2% loss on drying, 105 °C, 2 h expand Show data source
≤0.2% loss on drying, 110 °C expand Show data source
≤0.5% loss on drying, 105°C, 2 h expand Show data source
Extent of Labeling
30-60 Ci/mmol expand Show data source
Quality Level
GMP-COMPENDIA expand Show data source
Quality
meets analytical specification of Ph. Eur., BP, USP expand Show data source
λ
1 M in 1 M HCl expand Show data source
Pharmacopeia
testing & handling conforms to Pharmacopeia expand Show data source
Product Line
BioUltra expand Show data source
BioXtra expand Show data source
Linear Formula
NH2CH2COOH expand Show data source

DETAILS

DETAILS

MP Biomedicals MP Biomedicals DrugBank DrugBank Wikipedia Wikipedia Sigma Aldrich Sigma Aldrich TRC TRC
MP Biomedicals - 04808831 external link
Electrophoresis Grade Purity: > 99.5% Heavy metals (as Pb): 20 ppm Used for preparation of Tris-glycine buffers.
MP Biomedicals - 02194049 external link
ACS Reagent Grade
Purity: >98.5%
Heavy metals (as Pb): 20 ppm
MP Biomedicals - 02194681 external link
Cell Culture Reagent
Crystalline
Free Acid
MP Biomedicals - 02100191 external link
Crystalline
MP Biomedicals - 02194825 external link
Molecular Biology Reagent Purity: 99+% Ideal for all molecular biology applications and buffer preparations.
MP Biomedicals - 02100570 external link
Crystalline
Free Acid
MP Biomedicals - 04808822 external link
Electrophoresis Grade
Purity: > 99.5%
Heavy metals (as Pb): 20 ppm
Used for preparation of Tris-glycine buffers.
MP Biomedicals - 02199462 external link
USP Grade
White crystalline powder
DrugBank - DB00145 external link
Item Information
Drug Groups approved; nutraceutical
Description A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter. [PubChem]
Indication Supplemental glycine may have antispastic activity. Very early findings suggest it may also have antipsychotic activity as well as antioxidant and anti-inflammatory activities.
Pharmacology Helps trigger the release of oxygen to the energy requiring cell-making process; Important in the manufacturing of hormones responsible for a strong immune system.
Toxicity ORL-RAT LD50 7930 mg/kg, SCU-RAT LD50 5200 mg/kg, IVN-RAT LD50 2600 mg/kg, ORL-MUS LD50 4920 mg/kg; Doses of 1 gram daily are very well tolerated. Mild gastrointestinal symptoms are infrequently noted. In one study doses of 90 grams daily were also well tole.
Affected Organisms
Humans and other mammals
Biotransformation Hepatic
Absorption Absorbed from the small intestine via an active transport mechanism.
External Links
Wikipedia
PDRhealth
Sigma Aldrich - G8790 external link
Application
氨基酸可用于细胞培养基的研发以及现有培养基的配制。
Biochem/physiol Actions
脊髓中的抑制性神经递质,NMDA 受体的变构调节剂。
Sigma Aldrich - G7126 external link
Biochem/physiol Actions
Glycine is a non-chiral amino acid that can be synthesized in the body from the amino acid serine by Serine Hydroxymethyltransferase.
脊髓中的抑制性神经递质,NMDA 受体的变构调节剂。
包装
1 kg in poly bottle
10 mg in autosmp vl
100, 500 g in poly bottle
5, 25 kg in poly drum
法律信息
ReagentPlus 注册商标 Sigma-Aldrich Co. LLC
Sigma Aldrich - G5417 external link
Biochem/physiol Actions
Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
Packaging
Manufactured and Packaged under cGMP
Sigma Aldrich - G3649 external link
包装
serum bottle
Physical form
Aqueous solution containing 2% ethanol
Sigma Aldrich - 50046 external link
Biochem/physiol Actions
Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
Other Notes
Buffer component in the coupled phosphatase-kinase reaction for end labeling of restriction fragments1; Component of Tris-glycine reservoir buffer used in SDS-polyacrylamide gel electrophoresis in the characterization of in vitro translation products2.
Sigma Aldrich - 241261 external link
Biochem/physiol Actions
Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
Packaging
50 g in poly bottle
Sigma Aldrich - 94119 external link
Biochem/physiol Actions
Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
Sigma Aldrich - G8898 external link
Analysis Note
经过检测,可用于 PAGE 电极缓冲液和蛋白质印迹转移缓冲液。
Application
甘氨酸是用于聚丙烯酰胺凝胶电泳的 Tris-甘氨酸和 Tris-甘氨酸-SDS 运行缓冲液的成分1。甘氨酸也是蛋白质印迹 Towbin 转移缓冲液的成分2。
Biochem/physiol Actions
脊髓中的抑制性神经递质,NMDA 受体的变构调节剂。
Sigma Aldrich - 50056 external link
Biochem/physiol Actions
Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
Sigma Aldrich - 74834 external link
Biochem/physiol Actions
Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
Sigma Aldrich - G7403 external link
Biochem/physiol Actions
脊髓中的抑制性神经递质,NMDA 受体的变构调节剂。
Sigma Aldrich - 50049 external link
Biochem/physiol Actions
Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
Other Notes
Commonly used buffer substance in cryoenzymology1; For osmotic pressure maintenance in isoelectric focusing of erythrocytes2; In protein chemistry - salting-in effect3; Growth requirement of various microorganisms4.
Sigma Aldrich - 50052 external link
Biochem/physiol Actions
Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
Sigma Aldrich - 50058 external link
Biochem/physiol Actions
Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
Sigma Aldrich - 15527 external link
Biochem/physiol Actions
Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
Sigma Aldrich - 410225 external link
Biochem/physiol Actions
Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
Packaging
50, 250 g in poly bottle
Sigma Aldrich - 76524 external link
Analysis Note
This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO Guide 34. This CRM is traceable to NIST SRM.
Biochem/physiol Actions
Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
General description
Certified content by quantitative NMR incl. uncertainty and expiry are given in the certificate.Download your certificate at: http://www.sigma-aldrich.com.
Legal Information
TraceCERT is a registered trademark of Sigma-Aldrich Co. LLC
Sigma Aldrich - G6201 external link
Biochem/physiol Actions
Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
Sigma Aldrich - W328707 external link
Biochem/physiol Actions
Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
Packaging
1 kg in poly bottle
1 sample in glass bottle
10, 25 kg in fiber drum
Sigma Aldrich - 12-1210 external link
Biochem/physiol Actions
Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
Sigma Aldrich - 50050 external link
Biochem/physiol Actions
Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
Sigma Aldrich - 33226 external link
Biochem/physiol Actions
Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
Toronto Research Chemicals - G615990 external link
Glycine is a non-essential amino acid for human development. Glycine is an inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

REFERENCES

REFERENCES

From Suppliers Google Scholar IconGoogle Scholar PubMed iconPubMed Google Books IconGoogle Books
  • • Scott, D., et al.: J. Neurosci., 21, 3063 (2001)
  • • Laube, B., et al.: Neuropharmacology, 47, 994 (2001)
  • • Papadakis, M., et al.: J. Biol. Chem., 279, 14703 (2001)
  • • Chen, P., et al.: Mol. Pharmacol., 67, 1470 (2001)
  • • Wolosker, H., et al.: Mol. Neurobiol., 36
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PATENTS

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