(1R,3R,6R,10R,11S,13S,16S,17R)-8-tert-butyl-6,17-dihydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.01,11.03,7.07,11.013,17]nonadecane-5,15,18-trione

• ChemBase ID: 179893
• Molecular Formular: C20H24O9
• Molecular Mass: 408.39916
• Monoisotopic Mass: 408.14203235
• SMILES: [C@]123[C@]4(C5([C@H](O3)OC(=O)[C@@H]5O)C(C[C@H]4OC2=O)C(C)(C)C)C[C@H]2[C@@]1([C@@H](C(=O)O2)C)O
• Canonical SMILES: O=C1O[C@@H]2[C@@]([C@@H]1C)(O)[C@@]13[C@]4(C2)[C@H](OC3=O)CC(C24[C@H](O1)OC(=O)[C@@H]2O)C(C)(C)C
• InChI: InChI=1S/C20H24O9/c1-7-12(22)26-10-6-17-9-5-8(16(2,3)4)18(17)11(21)13(23)28-15(18)29-20(17,14(24)27-9)19(7,10)25/h7-11,15,21,25H,5-6H2,1-4H3/t7-,8?,9-,10+,11+,15+,17-,18?,19-,20-/m1/s1
• InChIKey: FPUXKXIZEIDQKW-SFAAGJDISA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: (1R,3R,6R,10R,11S,13S,16S,17R)-8-tert-butyl-6,17-dihydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.0^1,^1^1.0^3,^7.0^7,^1^1.0^1^3,^1^7]nonadecane-5,15,18-trione
• IUPAC Traditional name: (1R,3R,6R,10R,11S,13S,16S,17R)-8-tert-butyl-6,17-dihydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.0^1,^1^1.0^3,^7.0^7,^1^1.0^1^3,^1^7]nonadecane-5,15,18-trione
• Synonyms: Ginkgolide A

Database IDs

• CAS Number: 24512-63-8
• PubChem SID: 164235803
• PubChem CID: 24883855

CALCULATED PROPERTIES

• Acid pKa: 11.767949
• H Acceptors: 6
• H Donor: 2
• LogD (pH = 5.5): 0.33678335
• LogD (pH = 7.4): 0.336765
• Log P: 0.3367836
• Molar Refractivity: 90.1745 cm^3
• Polarizability: 37.710293 Å^3
• Polar Surface Area: 128.59 Å^2
• Rotatable Bonds: 1
• Lipinski's Rule of Five: true

PROPERTIES

Pharmacology Properties

• Mechanism of Action: Potent platelet-activating factor receptor antagonist

Product Information

• Biological Source: Bitter principle from Ginkgo biloba
• Application(s): Antibacterial agent

REFERENCES

• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 1140