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30236-32-9 molecular structure
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N-{4-[(1S)-1-hydroxy-2-[(propan-2-yl)amino]ethyl]phenyl}methanesulfonamide hydrochloride

ChemBase ID: 179711
Molecular Formular: C12H21ClN2O3S
Molecular Mass: 308.82474
Monoisotopic Mass: 308.09614122
SMILES and InChIs

SMILES:
S(=O)(=O)(Nc1ccc(cc1)[C@H](CNC(C)C)O)C.Cl
Canonical SMILES:
CC(NC[C@@H](c1ccc(cc1)NS(=O)(=O)C)O)C.Cl
InChI:
InChI=1S/C12H20N2O3S.ClH/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17;/h4-7,9,12-15H,8H2,1-3H3;1H
InChIKey:
VIDRYROWYFWGSY-UHFFFAOYSA-N

Cite this record

CBID:179711 http://www.chembase.cn/molecule-179711.html

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NAMES AND DATABASE IDS

NAMES AND DATABASE IDS

Names Database IDs
IUPAC name
N-{4-[(1S)-1-hydroxy-2-[(propan-2-yl)amino]ethyl]phenyl}methanesulfonamide hydrochloride
IUPAC Traditional name
N-{4-[(1S)-1-hydroxy-2-[(propan-2-yl)amino]ethyl]phenyl}methanesulfonamide hydrochloride
Synonyms
Sotalol Hydrochloride
CAS Number
30236-32-9
PubChem SID
164235621
PubChem CID
9796652

DATA SOURCES

DATA SOURCES

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Data Source Data ID
PubChem 9796652 external link

CALCULATED PROPERTIES

CALCULATED PROPERTIES

JChem
Acid pKa 10.069403  H Acceptors
H Donor LogD (pH = 5.5) -3.138338 
LogD (pH = 7.4) -2.1217964  Log P -0.395064 
Molar Refractivity 71.1191 cm3 Polarizability 28.832848 Å3
Polar Surface Area 78.43 Å2 Rotatable Bonds
Lipinski's Rule of Five true 

PROPERTIES

PROPERTIES

Pharmacology Properties Product Information Bioassay(PubChem)
Mechanism of Action
Beta-Adrenergic blocker expand Show data source
Potassium channel (K VR ) blocker expand Show data source
Salt Data
HCl expand Show data source
Application(s)
Antiarrhythmic agent expand Show data source

DETAILS

DETAILS

REFERENCES

REFERENCES

From Suppliers Google Scholar IconGoogle Scholar PubMed iconPubMed Google Books IconGoogle Books
  • • Uloth, R.H. et al., J. Med. Chem., 1966, 9, 88, (synth)
  • • Gartiez, D.A. et al., J. Pharm. Sci., 1972, 61, 1728, (ms)
  • • Gadret, M. et al., Acta Cryst. B, 1976, 32, 2757, (cryst struct)
  • • Schnelle, K., Adv. Clin. Pharmacol., 1978, 18, 111, (rev, props, anal)
  • • Gomoll, A.W. et al., Eur. J. Pharmacol., 1986, 132, 123, (pharmacol, isom)
  • • Singh, B.N. et al., Drugs, 1987, 34, 311, (rev, pharmacol)
  • • Am. J. Cardiol., Suppl., 1990, 89, 1A, (rev, pharmacol)
  • • Foster, R.T. et al., Anal. Profiles Drug Subst., 1992, 21, 573, (rev, sotalol)
  • • Singh, B.N. et al., J. Cardiovasc. Pharmacol., 1992, 20, S75, (rev, sotalol)
  • • Touboul, P., Eur. Heart J., 1993, 14, 24, (sotalol, dexsotalol)
  • • Funck-Brentano, C., Eur. Heart J., 1993, 14, 30, (sotalol, dexsotalol)
  • • Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 640
  • • Hohnloser, S.H. et al., N. Engl. J. Med., 1994, 331, 31, (rev)
  • • Advani, S. et al., Drugs, 1995, 49, 664, (dexsotalol, rev)
  • • Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, CCK250
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PATENTS

PATENTS

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INTERNET

INTERNET

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