(2R,3R)-2,3-dihydroxybutanedioic acid; 2-[(4R,5S,6S,7R,9R,11Z,13Z,15R,16R)-6-{[(2R,3R,4R,5S,6R)-5-{[(2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy}-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-16-ethyl-4-hydroxy-15-({[(2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxy}methyl)-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde

• ChemBase ID: 132528
• Molecular Formular: C50H83NO23
• Molecular Mass: 1066.18692
• Monoisotopic Mass: 1065.53558792
• SMILES: CC[C@@H]1[C@H](/C=C(\C=C/C(=O)[C@@H](C[C@@H]([C@@H]([C@H]([C@@H](CC(=O)O1)O)C)O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)C)O[C@H]1C[C@@]([C@H]([C@@H](O1)C)O)(C)O)N(C)C)O)CC=O)C)/C)CO[C@H]1[C@@H]([C@@H]([C@@H]([C@H](O1)C)O)OC)OC.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O
• Canonical SMILES: OC(=O)[C@@H]([C@H](C(=O)O)O)O.O=CC[C@H]1C[C@@H](C)C(=O)/C=C\C(=C/[C@@H]([C@H](OC(=O)C[C@H]([C@@H]([C@H]1O[C@@H]1O[C@H](C)[C@H]([C@@H]([C@H]1O)N(C)C)O[C@@H]1O[C@@H](C)[C@@H]([C@](C1)(C)O)O)C)O)CC)CO[C@@H]1O[C@H](C)[C@H]([C@H]([C@H]1OC)OC)O)\C
• InChI: InChI=1S/C46H77NO17.C4H6O6/c1-13-33-30(22-58-45-42(57-12)41(56-11)37(52)26(5)60-45)18-23(2)14-15-31(49)24(3)19-29(16-17-48)39(25(4)32(50)20-34(51)62-33)64-44-38(53)36(47(9)10)40(27(6)61-44)63-35-21-46(8,55)43(54)28(7)59-35;5-1(3(7)8)2(6)4(9)10/h14-15,17-18,24-30,32-33,35-45,50,52-55H,13,16,19-22H2,1-12H3;1-2,5-6H,(H,7,8)(H,9,10)/b15-14-,23-18-;/t24-,25+,26-,27-,28+,29+,30-,32-,33-,35+,36-,37-,38-,39-,40-,41-,42-,43+,44+,45-,46-;1-,2-/m11/s1
• InChIKey: ICVKYYINQHWDLM-YOMZPPEJSA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: (2R,3R)-2,3-dihydroxybutanedioic acid; 2-[(4R,5S,6S,7R,9R,11Z,13Z,15R,16R)-6-{[(2R,3R,4R,5S,6R)-5-{[(2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy}-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-16-ethyl-4-hydroxy-15-({[(2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxy}methyl)-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde
• IUPAC Traditional name: 2-[(4R,5S,6S,7R,9R,11Z,13Z,15R,16R)-6-{[(2R,3R,4R,5S,6R)-5-{[(2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy}-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-16-ethyl-4-hydroxy-15-({[(2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxy}methyl)-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde; L(+)-tartaric acid
• Synonyms: Tylosin tartrate; Tylosin solution; 泰乐菌素 酒石酸酯; 泰乐菌素 溶液

Database IDs

• CAS Number: 74610-55-2
• MDL Number: MFCD07783824
• PubChem SID: 24900350; 162226805; 24900364
• PubChem CID: 71308573

CALCULATED PROPERTIES

• Acid pKa: 12.436767
• H Acceptors: 17
• H Donor: 5
• LogD (pH = 5.5): 0.61862975
• LogD (pH = 7.4): 2.1053298
• Log P: 2.3159072
• Molar Refractivity: 232.2071 cm^3
• Polarizability: 93.33953 Å^3
• Polar Surface Area: 238.67 Å^2
• Rotatable Bonds: 16
• Lipinski's Rule of Five: false

PROPERTIES

Physical Property

• Solubility: H2O: ≤50 mg/mL
• Apperance: powder

Safety Information

• European Hazard Symbols: Harmful (Xn)
• German water hazard class: 2; 3
• Risk Statements: 42/43
• Safety Statements: 22-36/37-45
• GHS Pictograms: GHS08
• GHS Signal Word: Danger
• GHS Hazard statements: H317-H334
• GHS Precautionary statements: P261-P280-P342 + P311
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• Storage Temperature: 2-8°C

Product Information

• Concentration: 8 mg/mL in 0.9% NaCl
• Potency: ≥800 units/mg tylosin
• Suitability: suitable for cell culture
• Impurities: endotoxin, tested
• Sterility: sterile-filtered

DETAILS

Sigma Aldrich - T3397

Application
Recommended for use in cell culture applications at 1 ml/L.
Biochem/physiol Actions
Inhibits bacterial protein synthesis at the level of 50S ribosome (L27 protein) binding. Antimicrobial spectrum: Gram-positive bacteria and mycoplasma.
Other Notes
Formulated to contain 8 mg/ml tylosin in 0.9% sodium chloride.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

Sigma Aldrich - T6134

General description
泰乐菌素 A、B、C 和 D 酒石酸盐的混合物。
Application
Tylosin is a macrolide antibiotic commonly used in veterinary medicine. It is used to study protein synthesis at the level of the 50S ribosome, implant site abscess prevention in cattle, disposition kinetics1 and Mycoplasma gallisepticum and Mycoplasma meleagridis infections2.
Biochem/physiol Actions
Tylosin tartrate inhibits bacterial protein synthesis at the level of 50S ribosome (L27 protein) binding.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

Sigma Aldrich - T6271

Application
Recommended for use in cell culture applications at 8 mg/L.
Biochem/physiol Actions
Interferes with bacterial protein synthesis by binding to the 50S subunit.Antimicrobial spectrum: Gram-positive bacteria and mycoplasma.
General description
泰乐菌素 A、B、C 和 D 酒石酸盐的混合物。
Reconstitution
Stock solutions should be filter sterilized and stored at 2-8 °C. Stable at 37 °C for 3 days.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information