disodium 2-(phosphonatooxy)propane-1,3-diol hydrate

• ChemBase ID: 131815
• Molecular Formular: C3H9Na2O7P
• Molecular Mass: 234.052661
• Monoisotopic Mass: 233.98812782
• SMILES: C(C(CO)OP(=O)([O-])[O-])O.O.[Na+].[Na+]
• Canonical SMILES: OCC(OP(=O)([O-])[O-])CO.O.[Na+].[Na+]
• InChI: InChI=1S/C3H9O6P.2Na.H2O/c4-1-3(2-5)9-10(6,7)8;;;/h3-5H,1-2H2,(H2,6,7,8);;;1H2/q;2*+1;/p-2
• InChIKey: ROPZSVKNEIIIDE-UHFFFAOYSA-L

NAMES AND DATABASE IDS

Names

• IUPAC name: disodium 2-(phosphonatooxy)propane-1,3-diol hydrate
• IUPAC Traditional name: disodium glycerol 2-phosphate hydrate
• Synonyms: BGP; β-Glycerophosphate disodium salt hydrate; Glycerophosphate disodium salt hydrate; Glycerol phosphate disodium salt hydrate; Glycerol 2-phosphate disodium salt hydrate; 甘油-2-磷酸 二钠盐 水合物; β-甘油磷酸 二钠盐 水合物; 甘油磷酸酯 二钠盐 水合物

Database IDs

• CAS Number: 55073-41-1; 154804-51-0
• EC Number: 212-464-3
• MDL Number: MFCD00149082
• PubChem SID: 24895383; 162226092; 24895249; 24895257; 24895253
• PubChem CID: 16219387

CALCULATED PROPERTIES

• Acid pKa: 1.1346252
• H Acceptors: 5
• H Donor: 2
• LogD (pH = 5.5): -4.4191055
• LogD (pH = 7.4): -5.5677385
• Log P: -1.9625801
• Molar Refractivity: 29.1456 cm^3
• Polarizability: 12.625253 Å^3
• Polar Surface Area: 112.88 Å^2
• Rotatable Bonds: 4
• Lipinski's Rule of Five: true

PROPERTIES

Physical Property

• Apperance: powder
• Melting Point: 102-104 °C(lit.)

Safety Information

• RTECS: UA0600000
• German water hazard class: 3
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

Product Information

• Purity: ≥99.0% (titration)
• Suitability: suitable for cell culture; suitable for plant cell culture
• Impurities: ≤0.1% Inorganic phosphorus; ≤0.1% Insoluble matter; ≤0.20% L-α-isomer; ≤0.20% α-isomer; ≤0.5 mol % L-α-isomer; ≤1.0 mol % L-α-isomer; ≤2.4 mol % α-isomer((based on C3H7O6PNa2 With x H2O))
• Cation Traces: Al: ≤0.0005%; Ca: ≤0.001%; Cu: ≤0.0005%; Fe: ≤0.001%; K: ≤0.005%; Mg: ≤0.0005%; Pb: ≤0.001%; Zn: ≤0.0005%
• Antion Traces: chloride (Cl-): ≤0.05%; sulfate (SO42-): ≤0.05%
• Biological Source: from synthetic
• Product Line: BioUltra
• Linear Formula: (HOCH2)2CHOP(O)(ONa)2 · xH2O

DETAILS

Sigma Aldrich - G5422

Quality
Low inorganic phosphate content. Mixtures of α- and β-glycerophosphate have historically been used in microbiological media but high levels of inorganic (free) phosphate has been associated with the irregular growth of bacteria and unwanted precipitates.9
Application
β-Glycerophosphate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers.1 BGP is often used in combination with other phosphatase/protease inhibitors for broad spectrum inhibition.2,3 It functions as an organic phosphate donor4 and has been used in culture media for mesenchymal stem cell differentiation to osteoblast-type cells.5,6 BGP is also used to buffer M17 media for Lactococcus culture in recombinant protein expression.7,8
β-glycerophosphate is used in homegenization solutions for muscles extracts following fixation.
Initiates differentiation of bone-marrow-derived stem cells embedded in a natural collagen/chitosan gel designed for tissue engineering.

Sigma Aldrich - G9891

Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Application
β-Glycerophosphate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers.1 BGP is often used in combination with other phosphatase/protease inhibitors for broad spectrum inhibition.2,3 It functions as an organic phosphate donor4 and has been used in culture media for mesenchymal stem cell differentiation to osteoblast-type cells.5,6 BGP is also used to buffer M17 media for Lactococcus culture in recombinant protein expression.7,8
Glycero-2-phosphate is a component of dexamethasone based hormone cocktail used to induce mesechymal stem cell (MSC) differentiation into osteoblasts.
Initiates differentiation of bone-marrow-derived stem cells embedded in a natural collagen/chitosan gel designed for tissue engineering.

Sigma Aldrich - G6376

Application
β-Glycerophosphate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers.1 BGP is often used in combination with other phosphatase/protease inhibitors for broad spectrum inhibition.2,3 It functions as an organic phosphate donor4 and has been used in culture media for mesenchymal stem cell differentiation to osteoblast-type cells.5,6 BGP is also used to buffer M17 media for Lactococcus culture in recombinant protein expression.7,8
Initiates differentiation of bone-marrow-derived stem cells embedded in a natural collagen/chitosan gel designed for tissue engineering.

Sigma Aldrich - G6501

Application
Evaluated as phosphorus source in the cultivation of Pichia pastoris.1 Used along with chitosan to prepare biodegradable hydrogels.2
Physical form
Usually contains 50% β-isomer and 50% rac-α-isomer

Sigma Aldrich - G9422

Quality
Low inorganic phosphate content. Mixtures of α- and β-glycerophosphate have historically been used in microbiological media but high levels of inorganic (free) phosphate has been associated with the irregular growth of bacteria and unwanted precipitates.9
Application
β-Glycerophosphate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers.1 BGP is often used in combination with other phosphatase/protease inhibitors for broad spectrum inhibition.2,3 It functions as an organic phosphate donor4 and has been used in culture media for mesenchymal stem cell differentiation to osteoblast-type cells.5,6 BGP is also used to buffer M17 media for Lactococcus culture in recombinant protein expression.7,8
Initiates differentiation of bone-marrow-derived stem cells embedded in a natural collagen/chitosan gel designed for tissue engineering.

Sigma Aldrich - G6251

Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Application
β-Glycerophosphate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers.1 BGP is often used in combination with other phosphatase/protease inhibitors for broad spectrum inhibition.2,3 It functions as an organic phosphate donor4 and has been used in culture media for mesenchymal stem cell differentiation to osteoblast-type cells.5,6 BGP is also used to buffer M17 media for Lactococcus culture in recombinant protein expression.7,8
Initiates differentiation of bone-marrow-derived stem cells embedded in a natural collagen/chitosan gel designed for tissue engineering.