guanidine hydrochloride

• ChemBase ID: 102498
• Molecular Formular: CH6ClN3
• Molecular Mass: 95.53144
• Monoisotopic Mass: 95.02502489
• SMILES: Cl.NC(=N)N
• Canonical SMILES: NC(=N)N.Cl
• InChI: InChI=1S/CH5N3.ClH/c2-1(3)4;/h(H5,2,3,4);1H
• InChIKey: PJJJBBJSCAKJQF-UHFFFAOYSA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: guanidine hydrochloride
• IUPAC Traditional name: guanidine hydrochloride
• Synonyms: Guanidine (Aminoformamidine) HCl; GUANIDINE HYDROCHLORIDE, ULTRA PURE; Aminoformamidine hydrochloride; Aminomethanamidine hydrochloride; Guanidinium chloride; GUANIDINE HYDROCHLORIDE PRACTICAL GRADE; Guanidium chloride; GUANIDINE HYDROCHLORIDE ULTRA PURE; GUANIDINE HYDROCHLORIDE; Guanidine hydrochloride solution; Guanidine hydrochloride; Guanidine hydrochloride; Guanidinium chloride; 胍盐酸盐; 胍 盐酸盐 溶液; 亚氨基脲 盐酸盐; 亚氨脲 盐酸盐; 盐酸胍; 胍 盐酸盐; 盐酸胍

Database IDs

• CAS Number: 50-01-1
• EC Number: 200-002-3
• MDL Number: MFCD00013026
• Beilstein Number: 3591990
• Merck Index: 144562
• PubChem SID: 24895369; 162089942; 24873453; 24873457; 24895181; 24873454; 24895295; 24873456; 24895119; 24873455; 24895176
• PubChem CID: 5742; 10855382
• CHEBI ID: 32735
• Chemspider ID: 5540
• Unique Ingredient Identifier: 3YQC9ZY4YB
• Wikipedia Title: Guanidinium_chloride

CALCULATED PROPERTIES

• H Acceptors: 3
• H Donor: 3
• LogD (pH = 5.5): -3.6522877
• LogD (pH = 7.4): -3.6514976
• Log P: -1.236839
• Molar Refractivity: 25.8588 cm^3
• Polarizability: 5.61125 Å^3
• Polar Surface Area: 75.89 Å^2
• Rotatable Bonds: 0
• Lipinski's Rule of Five: true

PROPERTIES

Physical Property

• Solubility: H2O: soluble6 M; H2O: soluble6 M at 20 °C, clear, colorless; H2O: soluble6 M, clear (100 Hazen); H2O: soluble6 M, clear, colorless; very soluble in water and ethanol
• Apperance: orthorhombic bipyramidal crystals
• Melting Point: 178-185°C; 180-185 °C(lit.); 182.3°C; 184 °C
• Density: 1.18 g/mL at 25 °C(lit.); 1.344; 1.345 g/cm^3 at 20 °C; 1.354 g/cm^3 at 20 °C
• Refractive Index: n20/D 1.465
• Absorption Wavelength: A6M/260 nm, H2O ≤0.10; A6M/260, H2O ≤0.1; A6M/280, H2O ≤0.05; λ: 260 nm Amax: 0.03; λ: 260 nm Amax: 0.040; λ: 280 nm Amax: 0.02; λ: 280 nm Amax: 0.025
• Hydrophobicity(logP): -2.387
• pH: 4.5-6.0 (25 °C, 6 M in H2O); 4.5-6.0 (6 M in H2O); 4.5-7.5 (25 °C)

Safety Information

• Storage Condition: Room Temperature (15-30°C); Room Temperature (15-30°C), Desiccate
• Storage Warning: Hygroscopic
• RTECS: MF4300000
• European Hazard Symbols: X; Harmful (Xn)
• German water hazard class: 1; 2
• Risk Statements: 22-36/38; R:22-36/38
• Safety Statements: 22; 26; S:22
• TSCA Listed: 是
• GHS Pictograms: GHS07
• GHS Signal Word: Warning
• GHS Hazard statements: H302-H315-H319
• GHS Precautionary statements: P280-P305+P351+P338-P302+P352-P321-P362-P501A; P305 + P351 + P338
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves; Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

Pharmacology Properties

• Target: Others

Product Information

• Purity: ≥99%; ~99%; >99%; ≥98%; ≥99%; ≥99% (titration); ≥99.0%; ≥99.0% (AT); ≥99.5%; ≥99.5% (AT); ≥99.5% (titration); 92%; 95%; 98%; 99%
• Concentration: ~8 M in H2O; 8 M in H2O (filtered)
• Grade: for analytical purposes; for molecular biology; OPTICAL; PRACTICAL; SAJ special grade
• Salt Data: HCl
• Ignition Residue: ≤0.05%; ≤0.05% (as SO4); ≤0.1% (as SO4); ≤0.2% (as SO4)
• Impurities: DNases, none detected; Insoluble matter, passes filter test; insoluble matter, passes filter test; phosphatases, none detected; proteases, none detected; RNases, none detected
• Cation Traces: Al: ≤0.0005%; Al: ≤1 mg/kg; Al: ≤5 mg/kg; As: ≤0.0001%; As: ≤0.1 mg/kg; Ba: ≤0.0005%; Ba: ≤1 mg/kg; Ba: ≤5 mg/kg; Bi: ≤0.0005%; Bi: ≤1 mg/kg; Bi: ≤5 mg/kg; Ca: ≤0.001%; Ca: ≤10 mg/kg; Ca: ≤20 mg/kg; Ca: ≤5 mg/kg; Cd: ≤0.0005%; Cd: ≤1 mg/kg; Cd: ≤5 mg/kg; Co: ≤0.0005%; Co: ≤1 mg/kg; Co: ≤5 mg/kg; Cr: ≤0.0005%; Cr: ≤1 mg/kg; Cr: ≤5 mg/kg; Cu: ≤0.0005%; Cu: ≤1 mg/kg; Cu: ≤5 mg/kg; Fe: ≤0.0005%; Fe: ≤1 mg/kg; Fe: ≤5 mg/kg; K: ≤0.005%; K: ≤20 mg/kg; K: ≤50 mg/kg; Li: ≤0.0005%; Li: ≤1 mg/kg; Li: ≤5 mg/kg; Mg: ≤0.0005%; Mg: ≤1 mg/kg; Mg: ≤5 mg/kg; Mn: ≤0.0005%; Mn: ≤1 mg/kg; Mn: ≤5 mg/kg; Mo: ≤0.0005%; Mo: ≤1 mg/kg; Mo: ≤5 mg/kg; Na: ≤0.005%; Na: ≤20 mg/kg; Na: ≤50 mg/kg; Ni: ≤0.0005%; Ni: ≤1 mg/kg; Ni: ≤5 mg/kg; Pb: ≤0.0005%; Pb: ≤1 mg/kg; Pb: ≤5 mg/kg; Pb: ≤5 ppm; Sr: ≤0.0005%; Sr: ≤1 mg/kg; Sr: ≤5 mg/kg; Zn: ≤0.0005%; Zn: ≤1 mg/kg; Zn: ≤5 mg/kg
• Antion Traces: sulfate (SO42-): ≤0.005%; sulfate (SO42-): ≤50 mg/kg
• Contains: ≤0.4% SiO2 as anticaking agent
• Foreign Activity: DNase, RNase, none detected
• Loss on Drying: ≤0.05% loss on drying, 20 °C (HV); ≤0.05% loss on drying, HV, 20°C; ≤0.5% loss on drying, 20 °C (HV)
• Quality Level: ELITE
• λ: 6 M in H2O; neat
• Product Line: BioUltra
• Linear Formula: NH2C(=NH)NH2 · HCl
• Empirical Formula (Hill Notation): CH5N3 · HCl

DETAILS

MP Biomedicals - 02194826

Molecular Biology Reagent
Purity: 99+%

MP Biomedicals - 02105696

Crystalline
Purity: >9%
Forms clear, colorless solutions at 6.0 M concentration.
O.D. 260 nm of a 6.0 M solution: 0<03.

MP Biomedicals - 04820512

Purity: >99% O.D. (260 nm) of a 6 M solution: <0.03 Ammeline: none detected Protein denaturant for molecular weight determinations.

MP Biomedicals - 02151210

Optical Grade
Crystalline
Purity: ~99%
Produces clear, colorless solutions

MP Biomedicals - 04820539

Purity: >99%
O.D. (260 nm) of a 6 M solution: <0.03
Ammeline: none detected
Protein denaturant for molecular weight determinations.

MP Biomedicals - 04820540

Purity: >99% O.D. (260 nm) of a 6 M solution: <0.03 Ammeline: none detected Protein denaturant for molecular weight determinations.

MP Biomedicals - 02101905

Practical Grade, solution may be cloudy and yellow.
Crystalline
2-3% Water Insolubles

Sigma Aldrich - 50950

Application
Strong chaotropic agent useful for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary.
Packaging
1, 2.5 kg in poly bottle
250 g in poly bottle

Sigma Aldrich - G7153

Application
强效离液剂，用于蛋白质的变性以及后续复性。该强效变性剂可溶解不溶性或变性的蛋白质，如包涵体。可用作使蛋白质或酶复性为活性形式的第一步骤。可能还需要脲和二硫苏糖醇 (DTT)。

Sigma Aldrich - 50935

Application
Strong chaotropic agent useful for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary.
Other Notes
In the extraction and fractionation by cesium sulfate density gradient centrifugation of bovine nasal cartilage proteoglycan1; Induces subunit dissociation and unfolding of bovine liver glutamate dehydrogenase2; Dissociation of apolipoproteins of insect lipophorin3; Denaturation curve4.

Sigma Aldrich - G3272

Application
强效离液剂，用于蛋白质的变性以及后续复性。该强效变性剂可溶解不溶性或变性的蛋白质，如包涵体。可用作使蛋白质或酶复性为活性形式的第一步骤。可能还需要脲和二硫苏糖醇 (DTT)。

Sigma Aldrich - G4505

Application
强效离液剂，用于蛋白质的变性以及后续复性。该强效变性剂可溶解不溶性或变性的蛋白质，如包涵体。可用作使蛋白质或酶复性为活性形式的第一步骤。可能还需要脲和二硫苏糖醇 (DTT)。
包装
1 kg in poly bottle
2, 10, 25 kg in poly drum
25, 100, 500 g in poly bottle

Sigma Aldrich - 12-1665

Application
Strong chaotropic agent useful for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary.
Suitability
for biological purposes

Sigma Aldrich - 177253

Application
Strong chaotropic agent useful for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary.
Packaging
100 g in poly bottle

Sigma Aldrich - 77839

Application
Strong chaotropic agent useful for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary.

Sigma Aldrich - 12-1660

Application
Strong chaotropic agent useful for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary.

Sigma Aldrich - G4630

Application
强效离液剂，用于蛋白质的变性以及后续复性。该强效变性剂可溶解不溶性或变性的蛋白质，如包涵体。可用作使蛋白质或酶复性为活性形式的第一步骤。可能还需要脲和二硫苏糖醇 (DTT)。

Sigma Aldrich - 50933

Application
Strong chaotropic agent useful for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary.
Other Notes
Denaturant. Isolation of RNA1

Sigma Aldrich - G11705

Application
Strong chaotropic agent useful for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary.
Packaging
1 kg in poly bottle

Sigma Aldrich - 50939

Application
Strong chaotropic agent useful for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary.