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Arbutamine

Catalog No. DB01102 Name DrugBank
CAS Number 128470-16-6 Website http://www.ualberta.ca/
M. F. C18H23NO4 Telephone (780) 492-3111
M. W. 317.37952 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 973

SYNONYMS

IUPAC name
4-[(1R)-1-hydroxy-2-{[4-(4-hydroxyphenyl)butyl]amino}ethyl]benzene-1,2-diol
IUPAC Traditional name
arbutamine
Brand Name
GenESA

DATABASE IDS

CAS Number 128470-16-6
PubChem SID 46509010
PubChem CID 60789

PROPERTIES

Hydrophobicity(logP) 2.9

DETAILS

Description (English)
Item Information
Drug Groups approved
Description Arbutamine, administered through a closed-loop, computer-controlled drug-delivery system, is indicated to elicit acute cardiovascular responses, similar to those produced by exercise, in order to aid in diagnosing the presence or absence of coronary artery disease in patients who cannot exercise adequately .
Indication Used to elicit acute cardiovascular responses (cardiac stumulant), similar to those produced by exercise, in order to aid in diagnosing the presence or absence of coronary artery disease (CAD) in patients who cannot exercise adequately.
Affected Organisms
Humans and other mammals
Biotransformation Primarily metabolized to methoxyarbutamine. Another possible metabolite is ketoarbutamine. The metabolites of arbutamine appear to have less pharmacological activity and a longer half-life and than the parental drug.
Half Life Elimination half-life is approximately 8 minutes.
Protein Binding 58%

REFERENCES