Remikiren

• Catalog No.: DB00212
• CAS Number: 126222-34-2
• M. F.: C33H50N4O6S
• M. W.: 630.8383

SYNONYMS

• IUPAC name: (2S)-2-[(2R)-2-benzyl-3-(2-methylpropane-2-sulfonyl)propanamido]-N-[(2R,3S,4R)-1-cyclohexyl-4-cyclopropyl-3,4-dihydroxybutan-2-yl]-3-(1H-imidazol-5-yl)propanamide
• IUPAC Traditional name: (2S)-2-[(2R)-2-benzyl-3-(2-methylpropane-2-sulfonyl)propanamido]-N-[(2R,3S,4R)-1-cyclohexyl-4-cyclopropyl-3,4-dihydroxybutan-2-yl]-3-(3H-imidazol-4-yl)propanamide
• Synonyms: Ro 42-5892

DATABASE IDS

• PubChem CID: 5462340
• CAS Number: 126222-34-2
• PubChem SID: 46507286

PROPERTIES

• Hydrophobicity(logP): 3.9

DETAILS

Description (English)

• Drug Groups: approved
• Description: Remikiren is an orally active, high specificity renin inhibitor.
• Indication: For the treatment of hypertension and heart failure
• Pharmacology: Remikiren is an orally available renin inhibitor with an established blood pressure-lowering effect in patients with essential hypertension. No data are available on the renal effects of remikiren in humans. In patients with essential hypertension, a single oral dose of remikiren can induce a renal vasodilation, without affecting the GFR and despite a significant decrease in blood pressure. This systemic and renal hemodynamic response is more pronounced in case of a more activated renin-angiotensin system.
• Affected Organisms: Humans and other mammals
• Absorption: Absorbed following oral administration.
• Protein Binding: 83%
• References: Clozel JP, Fischli W: Discovery of remikiren as the first orally active renin inhibitor. Arzneimittelforschung. 1993 Feb;43(2A):260-2. [Pubmed] ; Richter WF, Whitby BR, Chou RC: Distribution of remikiren, a potent orally active inhibitor of human renin, in laboratory animals. Xenobiotica. 1996 Mar;26(3):243-54. [Pubmed]
• External Links: Wikipedia

REFERENCES

• Clozel JP, Fischli W: Discovery of remikiren as the first orally active renin inhibitor. Arzneimittelforschung. 1993 Feb;43(2A):260-2. Pubmed
• Richter WF, Whitby BR, Chou RC: Distribution of remikiren, a potent orally active inhibitor of human renin, in laboratory animals. Xenobiotica. 1996 Mar;26(3):243-54. Pubmed