Pentolinium

• Catalog No.: DB01090
• CAS Number: 52-62-0
• M. F.: C15H32N2++
• M. W.: 240.42798

SYNONYMS

• IUPAC name: 1-methyl-1-[5-(1-methylpyrrolidin-1-ium-1-yl)pentyl]pyrrolidin-1-ium
• IUPAC Traditional name: pentolinium
• Brand Name: Ansolysen
• Synonyms: Pentolonium; Pentolinium tartrate; Pentolonum

DATABASE IDS

• CAS Number: 52-62-0
• PubChem CID: 5850
• PubChem SID: 46507977

DETAILS

Description (English)

• Drug Groups: approved
• Description: A nicotinic antagonist that has been used as a ganglionic blocking agent in hypertension. [PubChem]
• Indication: Used to produce controlled hypotension during surgical procedures and in hypertensive crises.
• Pharmacology: Pentolinium acts as a ganglionic blocking agent. Pentolinium inhibits release of adrenaline and noradrenaline from adrenergic nerves. It is used as an antihypertensive, and can be administered orally, intramuscularly, and subcutaneously.
• Toxicity: Oral, mouse: LD₅₀ = 512 mg/kg; Oral, rat: LD₅₀ = 890 mg/kg.
• Affected Organisms: Humans and other mammals