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Acetophenazine

Catalog No. DB01063 Name DrugBank
CAS Number 2751-68-0 Website http://www.ualberta.ca/
M. F. C23H29N3O2S Telephone (780) 492-3111
M. W. 411.56026 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 934

SYNONYMS

IUPAC name
1-(10-{3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl}-10H-phenothiazin-2-yl)ethan-1-one
IUPAC Traditional name
@acetophenazine
Brand Name
Tindal

DATABASE IDS

CAS Number 2751-68-0

PROPERTIES

Hydrophobicity(logP) 3.1

DETAILS

Description (English)
Item Information
Drug Groups approved
Description Acetophenazine is an antipsychotic drug of moderate-potency. It is used in the treatment of disorganized and psychotic thinking. It is also used to help treat false perceptions (e.g. hallucinations or delusions). It primarily targets the dopamine D2 receptor.
Indication For the treatment of disorganized and psychotic thinking. Also used to help treat false perceptions (e.g. hallucinations or delusions.)
Pharmacology Acetophenzine is a phenothiazine antipsychotic intended for the management of schizophrenia and other psychotic disorders.
Affected Organisms
Humans and other mammals
References
Jones GL, Woodbury DM: Spin-label study of phenothiazine interactions with erythrocyte ghost membranes: a possible membrane-mediated antisickling action. J Pharmacol Exp Ther. 1978 Oct;207(1):203-11. [Pubmed]
Tam SW, Cook L: Sigma opiates and certain antipsychotic drugs mutually inhibit (+)-[3H] SKF 10,047 and [3H]haloperidol binding in guinea pig brain membranes. Proc Natl Acad Sci U S A. 1984 Sep;81(17):5618-21. [Pubmed]
External Links
Wikipedia

REFERENCES

  • Jones GL, Woodbury DM: Spin-label study of phenothiazine interactions with erythrocyte ghost membranes: a possible membrane-mediated antisickling action. J Pharmacol Exp Ther. 1978 Oct;207(1):203-11. Pubmed
  • Tam SW, Cook L: Sigma opiates and certain antipsychotic drugs mutually inhibit (+)-[3H] SKF 10,047 and [3H]haloperidol binding in guinea pig brain membranes. Proc Natl Acad Sci U S A. 1984 Sep;81(17):5618-21. Pubmed