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Praziquantel

Catalog No. DB01058 Name DrugBank
CAS Number 55268-74-1 Website http://www.ualberta.ca/
M. F. C19H24N2O2 Telephone (780) 492-3111
M. W. 312.40606 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 929

SYNONYMS

IUPAC name
2-cyclohexanecarbonyl-1H,2H,3H,4H,6H,7H,11bH-piperazino[2,1-a]isoquinolin-4-one
IUPAC Traditional name
praziquantel
Brand Name
Biltricide

DATABASE IDS

PubChem CID 4891
CAS Number 55268-74-1
PubChem SID 46507082

PROPERTIES

Hydrophobicity(logP) 2.5
Solubility 400 mg/L

DETAILS

Description (English)
Item Information
Drug Groups approved
Description An anthelmintic used in most schistosome and many cestode infestations. [PubChem]
Indication For the treatment of infections due to all species of schistosoma.
Pharmacology Praziquantel is an anthelmintic used in most schistosome and many cestode infestations. Praziquantel effects the permeability of the cell membrane resulting in the contraction of schistosomes. The drug further causes vacuolization and disintegration of the schistosome tegument. The effect is more marked on adult worms compared to young worms. An increased calcium influx may play an important role. Secondary effects are inhibition of glucose uptake, lowering of glycogen levels and stimulation of lactate release. The action of praziquantel is limited very specifically to trematodes and cestodes; nematodes (including filariae) are not affected.
Biotransformation renal
Absorption Rapidly absorbed (80%)
Half Life 0.8-1.5 hours (in serum)
Protein Binding 80 to 85%
References
Doenhoff MJ, Cioli D, Utzinger J: Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis. Curr Opin Infect Dis. 2008 Dec;21(6):659-67. [Pubmed]
McManus DP, Loukas A: Current status of vaccines for schistosomiasis. Clin Microbiol Rev. 2008 Jan;21(1):225-42. [Pubmed]
External Links
Wikipedia
RxList
Drugs.com

REFERENCES

  • Doenhoff MJ, Cioli D, Utzinger J: Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis. Curr Opin Infect Dis. 2008 Dec;21(6):659-67. Pubmed
  • McManus DP, Loukas A: Current status of vaccines for schistosomiasis. Clin Microbiol Rev. 2008 Jan;21(1):225-42. Pubmed