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Echothiophate

Catalog No. DB01057 Name DrugBank
CAS Number 6736-03-4 Website http://www.ualberta.ca/
M. F. C9H23NO3PS+ Telephone (780) 492-3111
M. W. 256.322581 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 928

SYNONYMS

IUPAC name
diethyl {[2-(trimethylazaniumyl)ethyl]sulfanyl}phosphonate
IUPAC Traditional name
echothiophate
Brand Name
Echodide
Phospholine Iodide
Synonyms
Phospholine Iodide
Phospholine
Echothiophate Iodide

DATABASE IDS

PubChem SID 46505944
CAS Number 6736-03-4
PubChem CID 10547

PROPERTIES

Hydrophobicity(logP) -2.25
Solubility Soluble

DETAILS

Description (English)
Item Information
Drug Groups approved
Description A potent, long-acting irreversible cholinesterase inhibitor used as an ocular hypertensive in the treatment of glaucoma. Occasionally used for accomodative esotropia.
Indication For use in the treatment of subacute or chronic angle-closure glaucoma after iridectomy or where surgery is refused or contraindicated.
Pharmacology Echothiophate Iodide is a potent, long-acting cholinesterase inhibitor used as a miotic in the treatment of glaucoma. Echothiophate iodide will depress both plasma and erythrocyte cholinesterase levels in most patients after a few weeks of eyedrop therapy.
Toxicity Side effects include blurred vision or change in near or distant vision and eye pain.
Affected Organisms
Humans and other mammals
References
Schmidt KG, Horowitz Y, Buckman G, Segev E, Levinger E, Geyer O: Lowering of IOP by echothiophate iodide in pseudophakic eyes with glaucoma. Curr Eye Res. 2010 Aug;35(8):698-702. [Pubmed]
Reddy RH: Echothiophate iodide: its use in accommodative esotropia (high Ac/A ratio). Indian J Ophthalmol. 1982 Jul;30(4):225. [Pubmed]
External Links
Wikipedia
RxList
Drugs.com

REFERENCES

  • Schmidt KG, Horowitz Y, Buckman G, Segev E, Levinger E, Geyer O: Lowering of IOP by echothiophate iodide in pseudophakic eyes with glaucoma. Curr Eye Res. 2010 Aug;35(8):698-702. Pubmed
  • Reddy RH: Echothiophate iodide: its use in accommodative esotropia (high Ac/A ratio). Indian J Ophthalmol. 1982 Jul;30(4):225. Pubmed