Echothiophate

• Catalog No.: DB01057
• CAS Number: 6736-03-4
• M. F.: C9H23NO3PS+
• M. W.: 256.322581

SYNONYMS

• IUPAC name: diethyl {[2-(trimethylazaniumyl)ethyl]sulfanyl}phosphonate
• IUPAC Traditional name: echothiophate
• Brand Name: Echodide; Phospholine Iodide
• Synonyms: Phospholine Iodide; Phospholine; Echothiophate Iodide

DATABASE IDS

• PubChem SID: 46505944
• CAS Number: 6736-03-4
• PubChem CID: 10547

PROPERTIES

• Hydrophobicity(logP): -2.25
• Solubility: Soluble

DETAILS

Description (English)

• Drug Groups: approved
• Description: A potent, long-acting irreversible cholinesterase inhibitor used as an ocular hypertensive in the treatment of glaucoma. Occasionally used for accomodative esotropia.
• Indication: For use in the treatment of subacute or chronic angle-closure glaucoma after iridectomy or where surgery is refused or contraindicated.
• Pharmacology: Echothiophate Iodide is a potent, long-acting cholinesterase inhibitor used as a miotic in the treatment of glaucoma. Echothiophate iodide will depress both plasma and erythrocyte cholinesterase levels in most patients after a few weeks of eyedrop therapy.
• Toxicity: Side effects include blurred vision or change in near or distant vision and eye pain.
• Affected Organisms: Humans and other mammals
• References: Schmidt KG, Horowitz Y, Buckman G, Segev E, Levinger E, Geyer O: Lowering of IOP by echothiophate iodide in pseudophakic eyes with glaucoma. Curr Eye Res. 2010 Aug;35(8):698-702. [Pubmed] ; Reddy RH: Echothiophate iodide: its use in accommodative esotropia (high Ac/A ratio). Indian J Ophthalmol. 1982 Jul;30(4):225. [Pubmed]
• External Links: Wikipedia; RxList; Drugs.com

REFERENCES

• Schmidt KG, Horowitz Y, Buckman G, Segev E, Levinger E, Geyer O: Lowering of IOP by echothiophate iodide in pseudophakic eyes with glaucoma. Curr Eye Res. 2010 Aug;35(8):698-702. Pubmed
• Reddy RH: Echothiophate iodide: its use in accommodative esotropia (high Ac/A ratio). Indian J Ophthalmol. 1982 Jul;30(4):225. Pubmed