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Ergoloid mesylate

Catalog No. DB01049 Name DrugBank
CAS Number 8067-24-1 Website http://www.ualberta.ca/
M. F. C33H45N5O5 Telephone (780) 492-3111
M. W. 591.7409 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 921

SYNONYMS

IUPAC name
N-[2-hydroxy-7-(2-methylbutan-2-yl)-5,8-dioxo-4-(propan-2-yl)-3-oxa-6,9-diazatricyclo[7.3.0.0^{2,6}]dodecan-4-yl]-6-methyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),9,12,14-tetraene-4-carboxamide
IUPAC Traditional name
CO-dergocrine mesylate
Brand Name
Hydergine
Hydergine LC
Dihydroergotoxin Methanesulfonate
Deapril-ST
Ischelium
Hydrogenated Ergot Alkaloids
Redergin
Trigot
Alkergot
Co-Dergocrine Mesylate
Dihydroergotoxin Mesilat
Dihydroergotoxin Mesylate
Dihydroergotoxine Methanesulphonate
Ergoloid Mesylates [Usan]
Gerimal
Hydergin
Circanol
Dihydroergotoxine Mesilate
Dihydroergotoxine Mesylate
Dihydroergotoxine Methanesulfonate

DATABASE IDS

CAS Number 8067-24-1

PROPERTIES

Hydrophobicity(logP) 2.8

DETAILS

Description (English)
Item Information
Drug Groups approved
Description Ergoloid mesylate is a dihydrogenated ergot (Claviceps purpurea) derivative alkaloid used as a vasodilator agent. Ergoloid Mesylate is the only vasodilator that has shown mild benefits in the treatment of vascular dementia.
Indication For use as an adjunct therapy for patients with dementia
Pharmacology Ergoloid Mesylate may increase cerebral metabolism and blood flow. The role of this medication in the therapy of dementia is controversial. A recent controlled study in patients with Alzheimer's disease found that there was no advantage to the use of ergoloid mesylates compared to placebo, suggesting that ergoloid mesylates may lower scores on some cognitive and behavioral rating scales. Further study is needed to determine the risk-benefit profile of ergoloid mesylates in the treatment of dementia.
Toxicity Symptoms of overdose include dyspnea, hypotension or hypertension, rapid weak pulse, delirium, nausea, vomiting, and bradycardia.
Affected Organisms
Humans and other mammals
Biotransformation Hepatic.
Absorption Rapidly but incompletely (approximately 25%) absorbed from the gastrointestinal tract. Approximately 50% of the absorbed dose is eliminated by first-pass metabolism.
Half Life 3.5 hours
Protein Binding 98-99%
External Links
Wikipedia

REFERENCES