Cromoglicate

• Catalog No.: DB01003
• CAS Number: 16110-51-3
• M. F.: C23H16O11
• M. W.: 468.36654

SYNONYMS

• IUPAC name: 5-{3-[(2-carboxy-4-oxo-4H-chromen-6-yl)oxy]-2-hydroxypropoxy}-4-oxo-4H-chromene-2-carboxylic acid
• IUPAC Traditional name: 5-{3-[(2-carboxy-4-oxochromen-6-yl)oxy]-2-hydroxypropoxy}-4-oxochromene-2-carboxylic acid
• Brand Name: Nasmil; Children's Nasalcrom; Lomusol; Alerion; Opticrom; Allergocrom; Apo-Cromolyn; Fivent; Gen-Cromoglycate; Intal; Lomudal; Nalcrom; Vividrin; Aarane; Alercom; Cromolyn Nasal Solution; Cromoptic; Cromovet; Gastrocrom; Gastrofrenal; Inostral; Intal Inhaler; Intal Syncroner; Introl; Lomupren; Lomuspray; Nalcron; Nasalcrom; Opticron; Rynacrom; Sofro; Vistacrom; Colimune; Crolom; Irtan
• Synonyms: Acide Cromoglicique [INN-French]; Acido Cromoglicico [INN-Spanish]; Cromoglycic Acid; Acidum Cromoglicicum [INN-Latin]; Cromoglicic Acid; Cromolyn; Cromoglycate

DATABASE IDS

• CAS Number: 16110-51-3

PROPERTIES

• Hydrophobicity(logP): 1.6
• Solubility: 210 mg/L

DETAILS

Description (English)

• Drug Groups: approved
• Description: A chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack. [PubChem]
• Indication: For the management of patients with bronchial asthma. Also used in the treatment of vernal keratoconjunctivitis, vernal conjunctivitis, and vernal keratitis.
• Pharmacology: Cromoglicate or cromolyn (USAN), a synthetic compound, inhibits antigen-induced bronchospasms and, hence, is used to treat asthma and allergic rhinitis. Cromoglicate is used as an ophthalmic solution to treat conjunctivitis and is taken orally to treat systemic mastocytosis and ulcerative colitis.
• Toxicity: Symptoms of overdose include cough, nasal congestion, nausea, sneezing and wheezing.
• Affected Organisms: Humans and other mammals
• Absorption: 1%
• Half Life: 1.3 hours
• References: Heinke S, Szucs G, Norris A, Droogmans G, Nilius B: Inhibition of volume-activated chloride currents in endothelial cells by chromones. Br J Pharmacol. 1995 Aug;115(8):1393-8. [Pubmed]
• External Links: Wikipedia; RxList

REFERENCES

• Heinke S, Szucs G, Norris A, Droogmans G, Nilius B: Inhibition of volume-activated chloride currents in endothelial cells by chromones. Br J Pharmacol. 1995 Aug;115(8):1393-8. Pubmed