Dipyridamole

• Catalog No.: DB00975
• CAS Number: 58-32-2
• M. F.: C24H40N8O4
• M. W.: 504.6256

SYNONYMS

• IUPAC name: 2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin-1-yl)pyrimido[5,4-d][1,3]diazin-2-yl}(2-hydroxyethyl)amino)ethan-1-ol
• IUPAC Traditional name: dipyridamole
• Brand Name: Corosan; Aggrenox; Peridamol; Agilease; Anginal; Apo-Dipyridamole Fc; Cardioflux; Cleridium 150; Coridil; Justpertin; Permiltin; Prandiol; Prandiol 75; RA 8; Stenocardil; Apo-Dipyridamole Sc; Apricor; Chilcolan; Cleridium; Coronarine; Coroxin; Curantyl; Dipyridan; IV Persantine; Kurantil; Natyl; Novo-Dipiradol; Persantin; Persantine; Piroan; Protangix; RA-8; Stenocardiol; Stimolcardio; Cardoxil; Coribon; Gulliostin
• Synonyms: Usaf Ge-12; Dipyridamine; Dypyridamol; Dipyudamine; Dipiridamol; Dipyridamol

DATABASE IDS

• PubChem SID: 46506292
• CAS Number: 58-32-2
• PubChem CID: 3108

PROPERTIES

• Hydrophobicity(logP): 1.5
• Solubility: Slightly

DETAILS

Description (English)

• Drug Groups: approved
• Description: A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
• Indication: For as an adjunct to coumarin anticoagulants in the prevention of postoperative thromboembolic complications of cardiac valve replacement and also used in prevention of angina.
• Pharmacology: Dipyridamole, a non-nitrate coronary vasodilator that also inhibits platelet aggregation, is combined with other anticoagulant drugs, such as warfarin, to prevent thrombosis in patients with valvular or vascular disorders. Dipyridamole is also used in myocardial perfusion imaging, as an antiplatelet agent, and in combination with aspirin for stroke prophylaxis.
• Toxicity: Hypotension, if it occurs, is likely to be of short duration, but a vasopressor drug may be used if necessary. The oral LD₅₀ in rats is greater than 6,000 mg/kg while in the dogs, the oral LD₅₀ is approximately 400 mg/kg. LD₅₀=8.4g/kg (orally in rat)
• Affected Organisms: Humans and other mammals
• Biotransformation: hepatic
• Absorption: 70%
• Half Life: 40 minutes
• Protein Binding: 99%
• Elimination: Dipyridamole is metabolized in the liver to the glucuronic acid conjugate and excreted with the bile.
• Distribution: * 1 to 2.5 L/kg
• Clearance: * 2.3-3.5 mL/min/kg
• References: Diener HC, Cunha L, Forbes C, Sivenius J, Smets P, Lowenthal A: European Stroke Prevention Study. 2. Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. J Neurol Sci. 1996 Nov;143(1-2):1-13. [Pubmed]
• External Links: Wikipedia; RxList; Drugs.com

REFERENCES

• Diener HC, Cunha L, Forbes C, Sivenius J, Smets P, Lowenthal A: European Stroke Prevention Study. 2. Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. J Neurol Sci. 1996 Nov;143(1-2):1-13. Pubmed