Selenium Sulfide

• Catalog No.: DB00971
• CAS Number: 7446-34-6
• M. F.: HSSe
• M. W.: 112.03294

SYNONYMS

• IUPAC name: sulfaneselone
• IUPAC Traditional name: selenium sulfide
• Brand Name: Selsun Blue Oily Formula; Exsel Lotion Shampoo; Selensulfid; Head & Shoulders Intensive Treatment Regular Formula Dandruff Lotion Shampoo; Exsel; Glo-Sel; Head & Shoulders Intensive Treatment Conditioning Formula Dandruff Lotion Shampoo; Sebusan; Selenium(IV) sulfide; Selsun Blue Dry Formula; Selsun Blue Extra Conditioning Formula; Selsun Blue Extra Medicated Formula; Selsun Blue Regular Formula; Head & Shoulders Intensive Treatment 2 in 1 (Persistent Dandruff Shampoo plus Conditioner in One) Formula Dandruff Lotion Shampoo; Selsun; Selsun Blue; Versel Lotion
• Synonyms: Sulfur selenide; Selenium sulphide; Selenium Disulfide; Selenium sulfide red powder; SeS

DATABASE IDS

• CAS Number: 7446-34-6
• PubChem SID: 46507535
• PubChem CID: 24011

PROPERTIES

• Solubility: Practically insoluble

DETAILS

Description (English)

• Drug Groups: approved
• Description: Selenium Sulfide is an antifungal agent as well as a cytostatic agent, slowing the growth of hyperproliferative cells in seborrhea. Selenium Sulfide is the active ingredient often used in shampoos for the treatment of dandruff, seborrheic dermatitis and tinea capitis, a fungal infection that is primarily a disease of preadolescent children.
• Indication: For treatment of tinea versicolor, tinea capitis, dandruff and seborrheic dermatitis of the scalp.
• Pharmacology: Selenium sulfide is an antifungal agent often used in shampoos for the treatment of dandruff and seborrheic dermatitis. Selenium sulfide is highly active in inhibiting the growth of P. ovale. It is also a proven cytostatic agent, slowing the growth of both hyperproliferative and normal cells in dandruff and seborrheic dermatitis. A 0.6% micronized form of selenium sulfide is also safe and effective for dandruff.
• Toxicity: No documented reports of serious toxicity in humans resulting from acute ingestion of selenium sulfide, however, acute toxicity studies in animals suggest that ingestion of large amounts could result in potential human toxicity.
• Affected Organisms: Humans and other mammals; Fungi; Bacteria
• Absorption: There is no substantial absorption through intact skin. Absorption has been reported in patients with open lesions on the scalp or in patients using a 1% cream on the back - a patient with scalp lesions that used selenium shampoos had a level of selenium sulfide as high as 32 μg/ml in her urine.
• References: Johnson BA, Nunley JR: Treatment of seborrheic dermatitis. Am Fam Physician. 2000 May 1;61(9):2703-10, 2713-4. [Pubmed] ; Chen C, Koch LH, Dice JE, Dempsey KK, Moskowitz AB, Barnes-Eley ML, Hubbard TW, Williams JV: A randomized, double-blind study comparing the efficacy of selenium sulfide shampoo 1% and ciclopirox shampoo 1% as adjunctive treatments for tinea capitis in children. Pediatr Dermatol. 2010 Sep-Oct;27(5):459-62. doi: 10.1111/j.1525-1470.2010.01093.x. Epub 2010 Aug 24. [Pubmed]
• External Links: Wikipedia; RxList; Drugs.com

REFERENCES

• Johnson BA, Nunley JR: Treatment of seborrheic dermatitis. Am Fam Physician. 2000 May 1;61(9):2703-10, 2713-4. Pubmed
• Chen C, Koch LH, Dice JE, Dempsey KK, Moskowitz AB, Barnes-Eley ML, Hubbard TW, Williams JV: A randomized, double-blind study comparing the efficacy of selenium sulfide shampoo 1% and ciclopirox shampoo 1% as adjunctive treatments for tinea capitis in children. Pediatr Dermatol. 2010 Sep-Oct;27(5):459-62. doi: 10.1111/j.1525-1470.2010.01093.x. Epub 2010 Aug 24. Pubmed