Methylprednisolone

• Catalog No.: DB00959
• CAS Number: 83-43-2
• M. F.: C22H30O5
• M. W.: 374.4706

SYNONYMS

• IUPAC name: (1S,2R,8S,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,8,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one
• IUPAC Traditional name: methylprednisolone
• Brand Name: Firmacort; Besonia; Metrisone; Medrol Dosepak; Solomet; Mesopren; Dopomedrol; Medesone; Medlone 21; Medrol Adt Pak; Metrocort; Metysolon; Reactenol; Urbason; Artisone-Wyeth; Esametone; Lemod; Medixon; Medrate; Medrone; Metastab; Metilbetasone; Moderin; Nirypan; Noretona; Predni N Tablinen; Promacortine; Sieropresol; Summicort; Suprametil; Urbasone; Wyacort
• Synonyms: Methylprednisolon; Methylprednisolonum [INN-Latin]; Metilprednisolona [INN-Spanish]; Methyleneprednisolone; Metilprednisolone [Dcit]; 6alpha-Methylprednisolone

DATABASE IDS

• PubChem SID: 46504885
• PubChem CID: 6741
• CAS Number: 83-43-2

PROPERTIES

• Hydrophobicity(logP): 1.5
• Solubility: 120 mg/L

DETAILS

Description (English)

• Drug Groups: approved
• Description: A prednisolone derivative with similar anti-inflammatory action. [PubChem]
• Indication: Adjunctive therapy for short-term administration in rheumatoid arthritis.
• Pharmacology: Methylprednisolone and its derivatives, methylprednisolone sodium succinate and methylprednisolone acetate, are synthetic glucocorticoids used as antiinflammatory or immunosuppressive agents.
• Toxicity: LD₅₀=2000 mg/kg (orally in rat)
• Affected Organisms: Humans and other mammals
• Biotransformation: Hepatic
• Absorption: Oral bioavailability 80-99%
• Half Life: 1-3 hours
• Protein Binding: 78%
• References: Sloka JS, Stefanelli M: The mechanism of action of methylprednisolone in the treatment of multiple sclerosis. Mult Scler. 2005 Aug;11(4):425-32. [Pubmed]
• External Links: Wikipedia; RxList; Drugs.com

REFERENCES

• Sloka JS, Stefanelli M: The mechanism of action of methylprednisolone in the treatment of multiple sclerosis. Mult Scler. 2005 Aug;11(4):425-32. Pubmed