Cycrimine

• Catalog No.: DB00942
• CAS Number: 77-39-4
• M. F.: C19H29NO
• M. W.: 287.43966

SYNONYMS

• IUPAC name: 1-cyclopentyl-1-phenyl-3-(piperidin-1-yl)propan-1-ol
• IUPAC Traditional name: cycrimine
• Brand Name: Pagitane
• Synonyms: Cycrimine hydrochloride

DATABASE IDS

• CAS Number: 77-39-4
• PubChem SID: 46506736
• PubChem CID: 2911

PROPERTIES

• Hydrophobicity(logP): 4

DETAILS

Description (English)

• Drug Groups: approved
• Description: Cycrimine is a drug used to reduce levels of acetylcholine to return a balance with dopamine in the treatment and management of Parkinson's disease.
• Indication: For treatment and management of Parkinson's disease.
• Pharmacology: Cycrimine is a central anticholenergic used in the treatment of the symptoms of Parkinson's disease. It is a drug used to reduce levels of acetylcholine. Acetylcholine is usually in balance with dopamine neurotransmitters, however lower levels of dopamine are present in the brain of patients suffering from Parkinson's disease. By lowering levels of acetylcholine, it is thought that this balance may be restored.
• Affected Organisms: Humans and other mammals
• Protein Binding: 14-21%
• References: Vedasiromoni JR, Ganguly DK: Cycrimine on rat diaphragm. Arch Int Pharmacodyn Ther. 1976 Jan;219(1):64-9. [Pubmed]

REFERENCES

• Vedasiromoni JR, Ganguly DK: Cycrimine on rat diaphragm. Arch Int Pharmacodyn Ther. 1976 Jan;219(1):64-9. Pubmed